A Dynamic Model to Assess Human Papillomavirus Vaccination Strategies in a Heterosexual Population Combined with Men Who have Sex with Men

Gao, Shasha; Martcheva, Maia; Miao, Hongyu; Liang, Rong

doi:10.1007/s11538-020-00830-y

Cited by 19 publications

(28 citation statements)

References 43 publications

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“…We found no changes in the evolution of HPV infection in this group. There were no changes in the decline of the infection even after increasing the vaccination coverage, in contrast to Gao S. et al [44], who suggests the best vaccination strategy is to vaccinate MSM. Bogaards J. et al [43] also suggested that HPV vaccination might be effective when given to MSM.…”

Section: Discussioncontrasting

confidence: 70%

“…They found a reduction in the prevalence of HPV16 among MSM exceeding vaccine coverage projections, illustrating the efficiency of prophylactic immunization even when the HPV vaccine is administered after sexual initiation [43]. In the same way, the modeling of Gao, S. et al [44] found that the heterosexual population gets great benefit, but MSM only get minor benefit from vaccinating heterosexual females or males.…”

Section: Discussionmentioning

confidence: 93%

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Impact of a Gender-Neutral HPV Vaccination Program in Men Who Have Sex with Men (MSM)

Díez‐Domingo

Sánchez-Alonso

Micó

et al. 2021

IJERPH

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A major challenge in human papillomavirus (HPV) vaccine programs is the universal gender-neutral recommendation, as well as estimation of its long-term effect. The objective of this study is to predict the added benefit of male vaccination, especially in men who have sex with men (MSM), and to analyze the impact of the program on society. We propose a mathematical model of the HPV infection based on a network paradigm. Data from Spain allowed constructing the sexual network. HPV force of infection was taken from literature. Different scenarios using variable vaccine coverage in both males and females were studied. Strong herd immunity is shown in the heterosexual population, with an important decrease of HPV 6/11 infections both in men and in unvaccinated women with an only-women vaccination at 14 years of age. No impact of this program occurred in the infection incidence in MSM. This group would only benefit from a vaccination program that includes males. However, the impact at short term would be lower than in heterosexual men. The protection of MSM can only be achieved by direct vaccination of males. This may have important consequences for public health.

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Section: Discussioncontrasting

confidence: 70%

Section: Discussionmentioning

confidence: 93%

Impact of a Gender-Neutral HPV Vaccination Program in Men Who Have Sex with Men (MSM)

Díez‐Domingo

Sánchez-Alonso

Micó

et al. 2021

IJERPH

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“…Damm et al found that the cost-effectiveness of additional vaccination for boys was highly dependent on the coverage in girls [26]. Some other papers investigated the impact of HPV vaccines and proper vaccine distributions without considering cost-effectiveness [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45]. Several of them suggested that girls-only policy was better than including boys, at least in the present situation [27][28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

“…Some other papers investigated the impact of HPV vaccines and proper vaccine distributions without considering cost-effectiveness [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45]. Several of them suggested that girls-only policy was better than including boys, at least in the present situation [27][28][29][30][31]. Vaccinating boys was only reasonable if the vaccination coverage for girls was moderate or high [33].…”

Section: Introductionmentioning

confidence: 99%

“…Waning immunity was also considered to be important, especially when studying persistent HPV infection and its associated cancer incidence [31,34]. The impact of HPV vaccination was also evaluated in the population of MSM [27,[44][45][46]. Díez-Domingo et al showed that MSM would not benefit by the herd immunity effect of vaccinating females [46].…”

Section: Introductionmentioning

confidence: 99%

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A two-sex model of human papillomavirus infection: Vaccination strategies and a case study

Gao

Martcheva

Miao

et al. 2021

Preprint

Self Cite

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Vaccination is effective in preventing human papillomavirus (HPV) infection. It still remains debatable whether males should be included in a vaccination program and unclear how to allocate the vaccine in genders to achieve the maximum benefits. In this paper, we use a two-sex model to assess HPV vaccination strategies and use the data from Guangxi Province in China as a case study. Both mathematical analysis and numerical simulations show that the basic reproduction number, an important indicator of the transmission potential of the infection, achieves its minimum when the priority of vaccination is given to the gender with a smaller recruit rate. Given a fixed amount of vaccine, splitting the vaccine evenly usually leads to a larger basic reproduction number and a higher prevalence of infection. Vaccination becomes less effective in reducing the infection once the vaccine amount exceeds the smaller recruit rate of the two genders. In the case study, we estimate the basic reproduction number is 1.0333 for HPV 16/18 in people aged 15-55. The minimal bivalent HPV vaccine needed for the disease prevalence to be below 0.05% is 24050 per year, which should be given to females. However, with this vaccination strategy it would require a very long time and a large amount of vaccine to achieve the goal. In contrast with allocating the same vaccine amount every year, we find that a variable vaccination strategy with more vaccine given in the beginning followed by less vaccine in later years can save time and total vaccine amount. The variable vaccination strategy illustrated in this study can help to better distribute the vaccine to reduce the HPV prevalence. Although this work is for HPV infection and the case study is for a province in China, the model, analysis and conclusions may be applicable to other sexually transmitted diseases in other regions or countries.

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Modeling the impact of screening awareness and vaccination on human papilloma virus transmission

Xue,

Zhou,

Zhang

2024

Math Methods in App Sciences

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In this work, a two‐sex deterministic model for human papillomavirus (HPV) is developed to assess the impact of screening awareness and vaccination on the transmission dynamics. We provide a detailed analysis of the HPV model and established results for boundedness of the solutions and existence of a positively invariant and attracting set. The basic reproduction number is characterized, and it is shown that the disease‐free equilibrium is locally asymptotically stable if and the system is uniformly persistent if . Sensitivity analysis of reveals that HPV vaccination can mitigate HPV transmission, and HPV vaccination along with screening can further reduce the spread of HPV infection. Numerical simulations showed that the public awareness of screening after being vaccinated is contributing to reduce the spread of epidemic, and the role of screening awareness in controlling the disease was significantly greater among men than women. Besides, the numerical simulations reveal that increasing vaccination rates for male is effective in controlling HPV transmission. Hence, it is necessary to enhance the screening for men. Moreover, increasing vaccination rates is more effective than increasing screening awareness in eliminating the epidemic.

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A Dynamic Model to Assess Human Papillomavirus Vaccination Strategies in a Heterosexual Population Combined with Men Who have Sex with Men

Cited by 19 publications

References 43 publications

Impact of a Gender-Neutral HPV Vaccination Program in Men Who Have Sex with Men (MSM)

Impact of a Gender-Neutral HPV Vaccination Program in Men Who Have Sex with Men (MSM)

A two-sex model of human papillomavirus infection: Vaccination strategies and a case study

Modeling the impact of screening awareness and vaccination on human papilloma virus transmission

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