A dynamic multiscale model of cerebral blood flow and autoregulation in the microvasculature

Daher, Ali; Payne, Stephen J.

doi:10.1016/j.apm.2023.06.035

Cited by 4 publications

(2 citation statements)

References 89 publications

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“…For the state MCAo & LMC/SA/DA-dil, SAs and DAs were dilated by 10%, which is the average peak dilation observed in vivo for pial vessels during functional hyperaemia [ 64 ]. Note that models for autoregulation are available [ 78 , 79 ]. However, as autoregulation is likely impaired during stroke [ 80 ] we decided to work with a more general state that allows us to analyze how SA & DA dilations could counteract the flow and pressure reductions caused by the MCAo.…”

Section: Methodsmentioning

confidence: 99%

The role of leptomeningeal collaterals in redistributing blood flow during stroke

Epp,

Glück,

Binder

et al. 2023

PLoS Comput Biol

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Leptomeningeal collaterals (LMCs) connect the main cerebral arteries and provide alternative pathways for blood flow during ischaemic stroke. This is beneficial for reducing infarct size and reperfusion success after treatment. However, a better understanding of how LMCs affect blood flow distribution is indispensable to improve therapeutic strategies. Here, we present a novel in silico approach that incorporates case-specific in vivo data into a computational model to simulate blood flow in large semi-realistic microvascular networks from two different mouse strains, characterised by having many and almost no LMCs between middle and anterior cerebral artery (MCA, ACA) territories. This framework is unique because our simulations are directly aligned with in vivo data. Moreover, it allows us to analyse perfusion characteristics quantitatively across all vessel types and for networks with no, few and many LMCs. We show that the occlusion of the MCA directly caused a redistribution of blood that was characterised by increased flow in LMCs. Interestingly, the improved perfusion of MCA-sided microvessels after dilating LMCs came at the cost of a reduced blood supply in other brain areas. This effect was enhanced in regions close to the watershed line and when the number of LMCs was increased. Additional dilations of surface and penetrating arteries after stroke improved perfusion across the entire vasculature and partially recovered flow in the obstructed region, especially in networks with many LMCs, which further underlines the role of LMCs during stroke.

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Section: Methodsmentioning

confidence: 99%

The role of leptomeningeal collaterals in redistributing blood flow during stroke

Epp,

Glück,

Binder

et al. 2023

PLoS Comput Biol

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show abstract

“…small values of ϵ in [ 15 , Eq 15], the use of a finite support function may lead to sharp fronts of the tracer. The same approach is pursued in [ 16 ]. An alternative solution is to use a smooth function like a Gaussian with infinite support and gradual decay, which means it can provide a more realistic representation of transitions and gradients, but still be unphysiological in terms of maximum range.…”

Section: Methodsmentioning

confidence: 99%

Perfusion estimation using synthetic MRI-based measurements and a porous media flow model

Lorentzen,

Nævdal,

Sævareid

et al. 2023

PLoS Comput Biol

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The measurement of perfusion and filtration of blood in biological tissue give rise to important clinical parameters used in diagnosis, follow-up, and therapy. In this paper, we address techniques for perfusion analysis using processed contrast agent concentration data from dynamic MRI acquisitions. A new methodology for analysis is evaluated and verified using synthetic data generated on a tissue geometry.

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The conducted vascular response as a mediator of hypercapnic cerebrovascular reactivity: A modelling study

Daher,

Payne

2024

Computers in Biology and Medicine

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A dynamic multiscale model of cerebral blood flow and autoregulation in the microvasculature

Cited by 4 publications

References 89 publications

The role of leptomeningeal collaterals in redistributing blood flow during stroke

The role of leptomeningeal collaterals in redistributing blood flow during stroke

Perfusion estimation using synthetic MRI-based measurements and a porous media flow model

The conducted vascular response as a mediator of hypercapnic cerebrovascular reactivity: A modelling study

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