A Dynamic Role of the Medial Temporal Lobe during Retrieval of Declarative Memory in Man

Petersson, Karl Magnus; Elfgren, Christina; Ingvar, Martin

doi:10.1006/nimg.1997.0276

Cited by 54 publications

(57 citation statements)

References 75 publications

(87 reference statements)

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“…These structures are involved in declarative and emotional memory processing. The amygdala is also involved in behavioral and autonomic emotional response to aversive stimuli (LeDoux, 1993;Squire and Zola, 1996;Petersson et al, 1997). We suggest that these deactivations may represent a coping strategy for handling an acute, but well-known painful situation.…”

Section: Discussionmentioning

confidence: 86%

A PET activation study of dynamic mechanical allodynia in patients with mononeuropathy

Petrović¹,

Ingvar²,

Stone‐Elander³

et al. 1999

Pain

152

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The objective of this study was to investigate the central processing of dynamic mechanical allodynia in patients with mononeuropathy. Regional cerebral blood¯ow, as an indicator of neuronal activity, was measured with positron emission tomography. Paired comparisons were made between three different states; rest, allodynia during brushing the painful skin area, and brushing of the homologous contralateral area. Bilateral activations were observed in the primary somatosensory cortex (S1) and the secondary somatosensory cortex (S2) during allodynia compared to rest. The S1 activation contralateral to the site of the stimulus was more expressed during allodynia than during innocuous touch. Signi®cant activations of the contralateral posterior parietal cortex, the periaqueductal gray (PAG), the thalamus bilaterally and motor areas were also observed in the allodynic state compared to both non-allodynic states. In the anterior cingulate cortex (ACC) there was only a suggested activation when the allodynic state was compared with the non-allodynic states. In order to account for the individual variability in the intensity of allodynia and ongoing spontaneous pain, rCBF was regressed on the individually reported pain intensity, and signi®cant covariations were observed in the ACC and the right anterior insula. Signi®cantly decreased regional blood¯ow was observed bilaterally in the medial and lateral temporal lobe as well as in the occipital and posterior cingulate cortices when the allodynic state was compared to the non-painful conditions. This ®nding is consistent with previous studies suggesting attentional modulation and a central coping strategy for known and expected painful stimuli. Involvement of the medial pain system has previously been reported in patients with mononeuropathy during ongoing spontaneous pain. This study reveals a bilateral activation of the lateral pain system as well as involvement of the medial pain system during dynamic mechanical allodynia in patients with mononeuropathy. q 1999 International Association for the Study of Pain. Published by Elsevier Science B.V.

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Section: Discussionmentioning

confidence: 86%

A PET activation study of dynamic mechanical allodynia in patients with mononeuropathy

Petrović¹,

Ingvar²,

Stone‐Elander³

et al. 1999

Pain

152

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“…We also excluded studies that examined only a single region of interest (e.g., ref. 35). Finally, for studies reporting overlapping data (e.g., refs.…”

Section: Resultsmentioning

confidence: 99%

Prefrontal cortex and episodic memory retrieval mode

Lepage

Ghaffar²,

Nyberg³

et al. 2000

Proc. Natl. Acad. Sci. U.S.A.

493

262

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A multistudy analysis of positron emission tomography data identified three right prefrontal and two left prefrontal cortical sites, as well as a region in the anterior cingulate gyrus, where neuronal activity is correlated with the maintenance of episodic memory retrieval mode (REMO), a basic and necessary condition of remembering past experiences. The right prefrontal sites were near the frontal pole [Brodmann's area (BA) 10], frontal operculum (BA 47͞45), and lateral dorsal area (BA 8͞9). The two left prefrontal sites were homotopical with the right frontal pole and opercular sites. The same kinds of REMO sites were not observed in any other cerebral region. Many previous functional neuroimaging studies of episodic memory retrieval have reported activations near the frontal REMO sites identified here, although their function has not been clear. Many of these, too, probably have signaled their involvement in REMO. We propose that REMO activations largely if not entirely account for the frontal hemispheric asymmetry of retrieval as described by the original hemispheric encoding retrieval asymmetry model.

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“…The lack of detectable response may reside in the adaptive or learning mechanism that a familiarized mental task does not require the same degree of neuronal activity (magnitude of change and the amount of neurons) as in the naive situation (Jenkins et al 1994;Petersson et al 1997;Raichle 1997).…”

Section: (B) Thalamusmentioning

confidence: 99%

Pain and functional imaging

Ingvar

1999

Phil. Trans. R. Soc. Lond. B

Self Cite

227

152

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Functional neuroimaging has fundamentally changed our knowledge about the cerebral representation of pain. For the ¢rst time it has been possible to delineate the functional anatomy of di¡erent aspects of pain in the medial and lateral pain systems in the brain. The rapid developments in imaging methods over the past years have led to a consensus in the description of the central pain responses between di¡erent studies and also to a de¢nition of a central pain matrix with specialized subfunctions in man. In the near future we will see studies where a systems perspective allows for a better understanding of the regulatory mechanisms in the higher-order frontal and parietal cortices. Also, pending the development of experimental paradigms, the functional anatomy of the emotional aspects of pain will become better known.

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A Dynamic Role of the Medial Temporal Lobe during Retrieval of Declarative Memory in Man

Cited by 54 publications

References 75 publications

A PET activation study of dynamic mechanical allodynia in patients with mononeuropathy

A PET activation study of dynamic mechanical allodynia in patients with mononeuropathy

Prefrontal cortex and episodic memory retrieval mode

Pain and functional imaging

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