In this article we present the influence of a Hamiltonian saddle-node bifurcation on the highdimensional phase space structures that mediate reaction dynamics. To achieve this goal, we identify the phase space invariant manifolds using Lagrangian descriptors, which is a trajectorybased diagnostic suitable for the construction of a complete "phase space tomography" by means of analyzing dynamics on low-dimensional slices. First, we build a Hamiltonian system with one degree-of-freedom (DoF) that models reaction, and study the effect of adding a parameter to the potential energy function that controls the depth of the well. Then, we extend this framework to a saddle-node bifurcation for a two DoF Hamiltonian, constructed by coupling a harmonic oscillator, i.e. a bath mode, to the other reactive DoF in the system. For this problem, we describe the phase space structures associated with the rank-1 saddle equilibrium point in the bottleneck region, which is a Normally Hyperbolic Invariant Manifold (NHIM) and its stable and unstable manifolds.Finally, we address the qualitative changes in the reaction dynamics of the Hamiltonian system due to changes in the well depth of the potential energy surface that gives rise to the saddle-node bifurcation.