A Facial Synthesis and Anticancer Activity of (Z)‐2‐((5‐(4‐nitrobenzylidene)‐4‐oxo‐4,5‐dihydrothiazol‐2‐yl)amino)‐substituted Acid

Abstract

In order to explore the anticancer and antimicrobial activity associated with the thiazole framework, we synthesized the new series (Z)‐2‐((5‐(4‐nitrobenzylidene)‐4‐oxo‐4,5‐dihydrothiazol‐2‐yl)amino)‐substituted acid derivatives 6a–l. All the synthesized compounds were evaluated for anticancer and antimicrobial activity in vitro. Among these, the compounds 6a, 6b, 6c, 6e, 6f, 6g, 6h, 6i, 6j, and 6k showed highest antibacterial and antifungal activity. The compound 6a exhibited significant antibacterial activity against Bacillussubtilis, whereas compound 6j displays significant antifungal activity against fungal strains, that is, A. oryzae. The in vitro anticancer studies revealed that 6e, 6g, 6h, 6k, and 6l are the most active compounds against MCF‐7 and BT‐474 human breast cancer cell lines, which can be regarded as the promising drug candidate for development of anticancer drugs.

Synthesis of substituted pyrimidine using ZnFe2O4 nanocatalyst via one pot multi‐component reaction ultrasonic irradiation

“…With reference to above literature survey, in continuation to our previous research work of pharmaceutical moieties, 30–36 we have focused on synthesis of imidazo[1,2‐ a ]pyrimidine‐3‐carbonitrile derivatives (4a‐j ) using efficient and heterogeneous Zinc Ferrite (ZnFe 2 O 4 ) as nanocatalyzed one‐pot three‐component condensation reaction of benzimidazole ( 1 ) and malononitrile (3) with substituted aromatic aldehyde (2a‐j ) in methanol under ultrasonic irradiations. Author has selected normal spinel catalyst ZnFe 2 O 4 for present synthesis because ammonia molecule preferred to adsorbed on the surface of Zn atom of spinal zinc ferrite and it is used to removal of ammonia 37 .…”

Synthesis of (Z)-5-(substituted benzylidene)-2-((substituted phenyl) amino)thiazol-4(5H)-one analogues with antitubercular activity

“…In continuation of our work [20][21][22][23][24][25][26][27][28][29] here, we desire to state the advancement and execution of a methodology allowing for the synthesis of some new (Z)-5-(substituted benzylidene)-2-((substituted phenyl) amino)thiazol-4(5H)-one analogues. We have reported reaction under conventional method, which proceeds in short reaction time and give good to excellent yield.…”

Green synthesis of 4-methoxybenzylidene thiazole derivatives using potassium carbonate as base under ultrasound irradiation

“…32,33 Ultrasonic irradiation has been acknowledged as an innocuous, green technique and its application today has been a boon in serving a new pathway for several chemical processes like reagent activation in the synthesis of organic and inorganic compounds. 34 In view of the above considerations and in continuation of our previous work on thiazoles, thiazolidinones and sulphonamide derivatives of pharmaceutical interest, [35][36][37][38][39][40][41][42][43][44][45][46][47] we wish to report a simple, mild, competent and environmentally benign method for the synthesis and characterization of novel rhodanine derivatives 3, 4 and 6a-l by ultrasound irradiation and conventional technique via potassium carbonate catalyzed in water media.…”