2021
DOI: 10.1371/journal.pone.0246547
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A facile and comprehensive algorithm for electrical response identification in mouse retinal ganglion cells

Abstract: Retinal prostheses can restore the basic visual function of patients with retinal degeneration, which relies on effective electrical stimulation to evoke the physiological activities of retinal ganglion cells (RGCs). Current electrical stimulation strategies have defects such as unstable effects and insufficient stimulation positions, therefore, it is crucial to determine the optimal pulse parameters for precise and safe electrical stimulation. Biphasic voltages (cathode-first) with a pulse width of 25 ms and … Show more

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Cited by 2 publications
(4 citation statements)
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“…The signals recorded by MEA are used for spike detection, clustering and response analysis by the methods proposed in previous work [18]. The final result shows that there are three types of late response of RGC after electrical stimulation (Fig.…”
Section: B Statistical Results Of Different Response Type In Rgc Unitsmentioning
confidence: 98%
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“…The signals recorded by MEA are used for spike detection, clustering and response analysis by the methods proposed in previous work [18]. The final result shows that there are three types of late response of RGC after electrical stimulation (Fig.…”
Section: B Statistical Results Of Different Response Type In Rgc Unitsmentioning
confidence: 98%
“…The previously reported method [18] was used to detect the spikes of the preprocessed signal to obtain the spikes waveforms evoked by RGC. This method is mainly composed of stationary wavelet transform and Teager energy operator.…”
Section: B Spike Detectionmentioning
confidence: 99%
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“…For peripheral nervous system recordings, discrimination and identification of APs cannot lack spike sorting either (Metcalfe et al, 2021 ). Spike sorting is required to isolate retinal ganglion cells based on their multiunit activity recordings (Tsai et al, 2017 ; Pérez-Ortega et al, 2021 ) and identify their electrical responses (Li et al, 2021 ), but non-neural tissues can also benefit from it by applying spike sorting algorithms, i.e., on pancreatic biosignals (Iniguez-Lomeli et al, 2021 ).…”
Section: Discussionmentioning
confidence: 99%