A facile and efficient synthesis of highly functionalized pyrroles via a four-component one-pot reaction in the presence of Ni(II) Schiff base/SBA-15 heterogeneous catalyst

Abstract

Under favorable conditions, we have designed a one-pot multicomponent reaction combining aromatic amines, aldehydes, nitroalkanes, and 1-dicarbonyl compounds in conjunction with the presence of the Ni(II)-Schiff base/SBA-15 as a heterogeneous catalyst to generate a range of functionalized pyrroles in reasonable to excellent yields. We present a methodology that results in a high yield percentage, a short reaction time of approximately 8 hours, mild reaction conditions of 70°C, a wide range of substrates, the possibility of large-scale synthesis, low cost, and the avoidance of hazardous reagents/solvents. In addition, this method can synthesize more desirable pyrroles by adding or altering numerous functional groups to the reactants in a one-pot process. Speci cally, a Hammett plot variant was employed to evaluate the reaction effectively.