A Facile and Green Synthetic Route for Preparation of Heterostructure Fe₃O₄@Au Nanocomposites

Abstract

Abstract. Magnetic nanoparticles offer many exciting opportunities in biology and biomedicine, such as magnetic resonance imaging, magnetic hyperthermia therapy, biomedical diagnosis. The synthesis of multifunctional magnetic nanocomposites that possess watersolubility, magnetic properties and optical stability by a green method at room temperature in aqueous phase is still an unmet need. Here, we developed a simple and green method for preparing Fe3O4@Au integrated the super-paramagnetic and optical properties by seedmediated growth at mild condition in aqueous phase. The amphiphilic, non-ionic and nontoxic polymer poly(vinylpyrrolidone) (PVP) was used as a coupling agent for synthesis of Fe3O4@Au nanocomposites, which avoided the direct connection of Au and Fe3O4, and improved the saturation magnetization values of Fe3O4@Au to 40 emu/g at room temperature. We anticipate that the multifunctional Fe3O4@Au nanocomposites with high magnetic and good optical properties will provide a platform for potential diagnostic and therapeutic biomedical applications.

Multimodal Magnetic-Plasmonic Nanoparticles for Biomedical Applications

“…Eliminating the use of organic solvents throughout the synthetic process and using only biocompatible, non-toxic materials and reagents streamlines the synthesis for biological purposes. An aqueous synthetic method and biocompatible polymer was utilised in the synthesis of heterostructured Fe3O4@PVP@Au nanocomposites [24]. In this synthesis, PVP (polyvinylpyrrolidone) polymer was used to stabilise the Fe3O4 nanoparticles, and also to form a homogenous layer surrounding them that has a negative charge.…”

“…Hydroxylamine has frequently been utilised as a seeding and reducing agent in a number of cases for coating of magnetic nanoparticles with a plasmonic shell [24,27,28]. For example, Fantechi et al first synthesised ultrasmall Fe3O4 NPs using Massart's coprecipitation; then, hydroxylamine was used as a seeding agent for the gold NPs ( Figure 2) [28].…”

Hybrid Nanoparticles Based on Cobalt Ferrite and Gold: Preparation and Characterization

“…While numerous studies have demonstrated the production of hybrid gold-based nanoparticles, a reliable and predictable synthetic strategy that provides reproducibility has not been realized. There are two main approaches in the literature to synthesize these materials: In the first case, gold seeds with a diameter of 1-3 nm are prepared by the reduction with borohydride [27] or sodium citrate [28]. Then, the obtained seeds are added to magnetic particles.…”

Hybrid Nanoparticles Based on Cobalt Ferrite and Gold: Preparation and Characterization

“…While numerous studies have demonstrated the production of hybrid gold-based nanoparticles, a reliable and predictable synthetic strategy that provides reproducibility has not been realized. There are two main approaches in the literature to synthesize these materials: In the first case, gold seeds with a diameter 1-3 nm are prepared by the reduction with borohydride [23] or sodium citrate [24]. Then, the obtained seeds are added to magnetic particles.…”