A facile and high-sensitive bio-sensing of the V617F mutation in JAK2 gene by GSH-CdTe-QDs FRET-based sensor

Hakimi, Fatemeh; Khoshkam, Maryam; Sadighian, Somayeh; Ramazani, Ali

doi:10.1016/j.heliyon.2022.e12545

Cited by 4 publications

(2 citation statements)

References 52 publications

(61 reference statements)

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“…Many studies used QDs coencapsulating a cytotoxic drug in lipid nanoparticles as a theranostic tool for a xenografted murine melanoma model, which showed escalated blood circulation time. 245 Also, studies formulating surface-modified temperature-sensitive liposomes encapsulating chemotherapeutic agents and an MRI agent clearly showed enhanced drug release at the target site of the gliosarcoma. 246 These few examples of research studies show a tremendously promising field for developing better nanotheranostics for solid tumors.…”

Section: Interplay Of Known and Unknown Factorsmentioning

confidence: 99%

“…One major challenge for nanotheranostics assessment in tumor models is to simulate actual clinical conditions that must be addressed to restrict cancer progression and improve efficacy. Many studies used QDs coencapsulating a cytotoxic drug in lipid nanoparticles as a theranostic tool for a xenografted murine melanoma model, which showed escalated blood circulation time . Also, studies formulating surface-modified temperature-sensitive liposomes encapsulating chemotherapeutic agents and an MRI agent clearly showed enhanced drug release at the target site of the gliosarcoma .…”

Section: Interplay Of Known and Unknown Factorsmentioning

confidence: 99%

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Conjugated Nanoparticles for Solid Tumor Theranostics: Unraveling the Interplay of Known and Unknown Factors

Chavda,

Balar,

Nalla

et al. 2023

ACS Omega

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Cancer diagnoses have been increasing worldwide, and solid tumors are among the leading contributors to patient mortality, creating an enormous burden on the global healthcare system. Cancer is responsible for around 10.3 million deaths worldwide. Solid tumors are one of the most prevalent cancers observed in recent times. On the other hand, early diagnosis is a significant challenge that could save a person's life. Treatment with existing methods has pitfalls that limit the successful elimination of the disorder. Though nanoparticle-based imaging and therapeutics have shown a significant impact in healthcare, current methodologies for solid tumor treatment are insufficient. There are multiple complications associated with the diagnosis and management of solid tumors as well. Recently, surface-conjugated nanoparticles such as lipid nanoparticles, metallic nanoparticles, and quantum dots have shown positive results in solid tumor diagnostics and therapeutics in preclinical models. Other nanotheranostic material platforms such as plasmonic theranostics, magnetotheranostics, hybrid nanotheranostics, and graphene theranostics have also been explored. These nanoparticle theranostics ensure the appropriate targeting of tumors along with selective delivery of cargos (both imaging and therapeutic probes) without affecting the surrounding healthy tissues. Though they have multiple applications, nanoparticles still possess numerous limitations that need to be addressed in order to be fully utilized in the clinic. In this review, we outline the importance of materials and design strategies used to engineer nanoparticles in the treatment and diagnosis of solid tumors and how effectively each method overcomes the drawbacks of the current techniques. We also highlight the gaps in each material platform and how design considerations can address their limitations in future research directions.

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Section: Interplay Of Known and Unknown Factorsmentioning

confidence: 99%

Section: Interplay Of Known and Unknown Factorsmentioning

confidence: 99%