A facile and versatile protocol for the one-pot PhI(OAc) 2 mediated divergent synthesis of quinazolines from 2-aminobenzylamine

Synergistic catalysis on Fe–Nx sites and Fe nanoparticles for efficient synthesis of quinolines and quinazolinones via oxidative coupling of amines and aldehydes

“…8 Despite these signicant advances, the most classical and general approaches for the synthesis of quinazolines and quinazolinones still strongly rely on the condensation between o-aminobenzylamines and aldehydes followed by the oxidation of the resulting aminal intermediates in the laboratory and industry. However, this protocol generally requires the use of a large excess of toxic oxidants, such as DDQ, 9 MnO 2 , 10 PhI(OAc) 2 , 11 and NaClO, 12 or homogeneous transition metal complexes ligated with well-dened ligands, 8d,13 which signicantly limit its practical application, especially for pharmaceutical synthesis. Therefore, the development of efficient, stable and cost-effective heterogeneous non-precious metal catalysts for accessing quinazolines and quinazolinones is highly desirable.…”

Cationic IrIII Emitters with Near‐Infrared Emission Beyond 800 nm and Their Use in Light‐Emitting Electrochemical Cells

“…For the reduction voltammograms, 0.1 m tetra‐ n ‐butylammonium hexafluorophosphate (TBAPF 6 ) in MeCN was used as the supporting electrolyte. 2,3‐Di‐ p ‐tolylbenzo[ g ]quinoxaline (mpqx), 2,3‐bis(4‐methoxyphenyl)benzo[ g ]quinoxaline (mopqx), and 2‐(quinolin‐2‐yl)quinazoline (qqz) were synthesized following procedures reported in the literature . Cyclometalated iridium dichloro‐bridged dimers with the general formula [(C^N) 2 Ir(μ‐Cl) 2 Ir(C^N) 2 ] were prepared according to procedures reported in the literature .…”

“…2,3-Di-p-tolylbenzo[g]quinoxaline (mpqx), 2,3-bis(4-methoxyphenyl)benzo[g]quinoxaline (mopqx), and 2-(quinolin-2-yl)quinazoline (qqz) were synthesized following procedures reported in the literature. [13,14] Cyclometalated iridium dichloro-bridged dimers with the general formula [(C^N) 2 Ir(m-Cl) 2 Ir(C^N) 2 ]w ere prepared according to procedures reported in the literature. [15] All experiments involving IrCl 3 ·3H 2 Oo ra ny other iridium species were carried out in an inert atmosphere.…”

K2S2O8-mediated coupling of 6-amino-7-aminomethyl-thiazolino-pyridones with aldehydes to construct amyloid affecting pyrimidine-fused thiazolino-2-pyridones

“…Oxidative condensation of 2-aminobenzylamines with aldehydes is an attractive strategy to construct the pyrimidine ring. 25 K 2 S 2 O 8 is a mild oxidant, which has been utilized in oxidative coupling reactions to construct nitrogen containing heterocycles. [26][27][28][29] Herein, we report K 2 S 2 O 8mediated aerobic oxidative coupling of 6-amino-7-(aminomethyl)-thiazolino-2-pyridones with aldehydes for the synthesis of a novel tricyclic pyrimidine fused 2-pyridone scaffold.…”