A facile catalyst-free one-pot three component synthesis of pharmacologically important indole-centered 4H-chromenes in a deep eutectic solvent (DES)

Alvi, Shakeel; Alam, Manawwer; Ali, Rashid

doi:10.1016/j.molliq.2023.122951

Cited by 5 publications

(2 citation statements)

References 49 publications

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“…Another recent article describes the results of the search for an efficient DES for the preparation of indolyl chromenes with biological activity through multicomponent reaction. In this study, reported by Alvi et al a model reaction between indole, salicylaldehyde, and malononitrile was used to screen several DES mixtures [ 79 ]. Of the DESs tested, ChCl/Urea (1:2), at a reaction temperature of 70 °C, rendered the best results, which translated to a yield of 98% and a reaction time of 30 min ( Scheme 15 ).…”

Section: Deep Eutectic Systemsmentioning

confidence: 99%

How Can Deep Eutectic Systems Promote Greener Processes in Medicinal Chemistry and Drug Discovery?

Domingues,

Duarte,

Jesus

2024

Pharmaceuticals

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Chemists in the medicinal chemistry field are constantly searching for alternatives towards more sustainable and eco-friendly processes for the design and synthesis of drug candidates. The pharmaceutical industry is one of the most polluting industries, having a high E-factor, which is driving the adoption of more sustainable processes not only for new drug candidates, but also in the production of well-established active pharmaceutical ingredients. Deep eutectic systems (DESs) have emerged as a greener alternative to ionic liquids, and their potential to substitute traditional organic solvents in drug discovery has raised interest among scientists. With the use of DESs as alternative solvents, the processes become more attractive in terms of eco-friendliness and recyclability. Furthermore, they might be more effective through making the process simpler, faster, and with maximum efficiency. This review will be focused on the role and application of deep eutectic systems in drug discovery, using biocatalytic processes and traditional organic chemical reactions, as new environmentally benign alternative solvents. Furthermore, herein we also show that DESs, if used in the pharmaceutical industry, may have a significant effect on lowering production costs and decreasing the impact of this industry on the quality of the environment.

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Section: Deep Eutectic Systemsmentioning

confidence: 99%

How Can Deep Eutectic Systems Promote Greener Processes in Medicinal Chemistry and Drug Discovery?

Domingues,

Duarte,

Jesus

2024

Pharmaceuticals

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“…Undoubtedly, heterocyclic compounds are omnipresent, for example, most of the natural products, drug molecules, and even our body also contains heterocyclic scaffold(s) [19,26,27]. Moreover, a plethora of vital synthetic molecules of particular Heterocycles-Based Ionic Liquids (ILs) in Transdermal Drug Delivery DOI: http://dx.doi.org/10.5772/intechopen.1005105 interest also consist of the heterocyclic ring system(s) in their structure [28][29][30][31][32][33][34]. Noticeably, most of the ILs also comprise the heterocyclic ring in their cationic portion, as detailed in Figure 1.…”

Section: Preparations Of Some Important Heterocyclic-based Ionic Liquidsmentioning

confidence: 99%

Heterocycles-Based Ionic Liquids (ILs) in Transdermal Drug Delivery

Khan,

Ali,

Farooqui

2024

Heterocyclic Chemistry - New Perspectives

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Transdermal drug delivery systems (TDDSs) have become immensely popular over the past few years owing to their safe and noninvasive administration of the drugs across the skin. The TDDSs have provided a better surrogate pathway over conventional routes such as skin patches and injections, thereby resulting in superior and easier acceptance by the patients, minimized side effects, and controlled delivery rates. While TDDSs present these advantages, they also come with their limitations, specifically in delivering both small and macro drug molecules that exhibit moderate solubility in water and/or commonly used volatile organic solvents. To subdue this obstacle, ionic liquids (ILs) are being considered as the potential media not only for the syntheses of drugs but also as suitable carriers for the efficient delivery of both small as well as macromolecules. In this particular book chapter, we have discussed the transdermal drug delivery (TDD) of various partially soluble drugs such as acyclovir, anti-inflammatory drugs like diclofenac and ibuprofen, various anticancer drugs, etc., through heterocyclic-based ILs. Moreover, some green routes for ILs syntheses, including fatty acid-based “amino acid ionic liquids” (FAAAE-ILs) and “magnetic surface-active ionic liquid surfactants” (MSAIL), have also been discussed highlighting their function as the potential transdermal drug delivery agent.

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A green and metal-free one-pot three-component synthesis of thiazolobenzimidazoles in sustainable deep eutectic solvent

Verma,

Sahay,

Nayak

et al. 2024

Inorganic Chemistry Communications

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A facile catalyst-free one-pot three component synthesis of pharmacologically important indole-centered 4H-chromenes in a deep eutectic solvent (DES)

Cited by 5 publications

References 49 publications

How Can Deep Eutectic Systems Promote Greener Processes in Medicinal Chemistry and Drug Discovery?

How Can Deep Eutectic Systems Promote Greener Processes in Medicinal Chemistry and Drug Discovery?

Heterocycles-Based Ionic Liquids (ILs) in Transdermal Drug Delivery

A green and metal-free one-pot three-component synthesis of thiazolobenzimidazoles in sustainable deep eutectic solvent

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