A facile composite nanoparticle promoted by photoelectron transfer and consumption for tumor combination therapy

Zhang, Yahui; Sha, Weizhou; Liu, Yang; Wang, Wei; Yuan, Zhi

doi:10.1039/d0qm00447b

Cited by 6 publications

(3 citation statements)

References 45 publications

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“…After entering the cell, it can be hydrolyzed to produce 2′,7′-dichlorodihydrofluorescein (DCFH). The intracellular ROS can oxidize the nonfluorescent DCFH to produce fluorescent 2′,7′-dichlorofluorescein (DCF) . HMPP, HMPP-C, HMPP-C&C, and HMPP-C&C-GOx were coincubated with cancer cells and then subjected to confocal imaging.…”

Section: Resultsmentioning

confidence: 99%

“…The intracellular ROS can oxidize the nonfluorescent DCFH to produce fluorescent 2′,7′-dichlorofluorescein (DCF). 41 HMPP, HMPP-C, HMPP-C&C, and HMPP-C&C-GOx were coincubated with cancer cells and then subjected to confocal imaging. As shown in Figure 2e,f, the green fluorescence intensity was approximately the same in the HMPP and HMPP-C groups, slightly higher in the HMPP-C&C group, and most pronounced in the HMPP-C&C-GOx group.…”

Section: Synthesis and Characterization Of Hmpp-candc-goxmentioning

confidence: 99%

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Hollow Mesoporous MnO₂ Nanospheres as Light Source-Free Carriers for Synergistic Starvation and Chemiexcited Photodynamic Tumor Therapy

Wang,

Yang,

Chen

et al. 2023

ACS Appl. Nano Mater.

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Photodynamic therapy (PDT) has limitations for deep tumors that cannot be reached by an external excitation light source, and it is a feasible strategy to use chemical energy instead of an external laser to excite the photosensitizer. Herein, biodegradable self-supplying cascade reactors with hollow mesoporous manganese dioxide (HMnO2) nanospheres as carriers were developed, which could improve the hypoxia characteristics of the tumor microenvironment (TME) for synergistic starvation therapy and chemiexcited PDT. The chemiluminescent substrate bis[2,4,5-trichloro-6-(pentyloxycarbonyl)phenyl] oxalate (CPPO) made the generation of reactive oxygen species (ROS) no longer rely on external light sources. Glucose oxidase (GOx) catalyzed glucose to produce a large amount of hydrogen peroxide (H2O2), which not only promoted the decomposition of the manganese dioxide shell to release the drugs but also produced oxygen (O2) to improve the tumor microenvironment and also stimulated the activation of CPPO for promoting the photosensitizer chlorin e6 (Ce6) to convert O2 into singlet oxygen (1O2), leading to the death of cancer cells. This cascade nanoreactor had a hydrodynamic diameter of approximately 140 nm, which greatly simplified the synthesis steps of nanoparticles and utilized the cascade reaction to maximize the efficacy of cancer treatment. Therefore, the self-supplying cascade strategy will provide a feasible and efficient way for cancer therapy in the future.

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Section: Resultsmentioning

confidence: 99%

Section: Synthesis and Characterization Of Hmpp-candc-goxmentioning

confidence: 99%

Hollow Mesoporous MnO₂ Nanospheres as Light Source-Free Carriers for Synergistic Starvation and Chemiexcited Photodynamic Tumor Therapy

Wang,

Yang,

Chen

et al. 2023

ACS Appl. Nano Mater.

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“…Considering the biosafety, temperature difference response ability, and ROS generation requirements, SnSe was selected as PEDT nanomaterials for the advantages of good biosafety, good photothermal conversion performance, superior thermoelectric efficiency, and appropriate valence/conduction band potentials. After combining Au nanoparticles onto the surface of SnSe, the photothermal conversion property was improved, and the migration and separation properties of e – and h + , which was activated by thermoelectric effects, could be significantly improved due to the potential difference between electron acceptor Au-NPs and SnSe nanosemiconductors, resulting in promoted h + –H 2 O half-reaction efficiency ( Wang et al, 2020a ; Zhang et al, 2020 ; Wang et al, 2021 ). Moreover, e – -rich Au-NPs could catalyze tumor endogenous H 2 O 2 into ∙OH with high reactivity, together with h + –H 2 O-induced ·OH generation.…”

Section: Introductionmentioning

confidence: 99%

Electron Transfer Strategies to Regulate Carriers’ Separation for Intensive Pyroelectric Dynamic Therapy With Simultaneous Photothermal Therapy

et al. 2022

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Endogenic heat shock proteins and uneven local heat distribution are two main problems in traditional tumor hyperthermia therapy strategies. Aiming at solving these problems, we designed Au–SnSe–PVP nanomaterials (ASNPs) by modifying Au nanoparticles (Au-NPs) and biocompatible PVP on SnSe nanorods via a new reactive oxygen species production strategy. The ASNPs with excellent photothermal conversion performance can produce thermoelectric effects in response to temperature differences during photothermal conversion. The modification of Au-NPs can attract free electron (e–) to accumulate and promote the separation of e– and holes (h+) in the thermoelectric process, thereby further promoting e–-rich Au-NPs-induced H2O2 homolysis and h+–H2O half-reaction to generate hydroxyl radicals, realizing the synergistic application of photothermal therapy and pyroelectric dynamic therapy in tumor treatment.

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A Diode‐Like Dye‐Cu Anisotropic Junction in a Coordination Polymer as a Logic State Ratchet for Intratumor Redox Photomodulation

Shi

Wang

et al. 2023

Angewandte Chemie

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Redox logic materials offer new avenues to modulate intracellular pathologic redox environment area‐specifically, but the unambiguity of redox logic states and their unidirectional and repetitive switchability are challenging to realize. By merging a bistable diisophthalic phenazine dye ligand with CuII salt, a multistable coordination polymer (CP) was constructed, of which the dye‐Cu anisotropic junction achieved the diode‐like unidirectional electron transfer and logic state ratchet for the first time. Radical cationic CP maintained OFF status with low toxicity in healthy tissues, but was reduced to the neutral SERVO state by the overexpressed glutathione (GSH) in hypoxic tumors. After photoirradiation, the stabilized charge‐separated ON status promoted photo‐Fenton reaction for reactive oxygen species (ROS) signal transduction, and simultaneously recovered the initial state for catalytic signal amplification of ROS, furnishing intratumor redox photomodulation for therapy.

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A facile composite nanoparticle promoted by photoelectron transfer and consumption for tumor combination therapy

Abstract: Titanium dioxide nanoparticle is a promising agent for oxygen-independent Type I PDT. However, the low separation efficiency of electron-hole pairs limits its application. It is reported that the Cu2(OH)PO4 can...

Cited by 6 publications

References 45 publications

Hollow Mesoporous MnO₂ Nanospheres as Light Source-Free Carriers for Synergistic Starvation and Chemiexcited Photodynamic Tumor Therapy

Hollow Mesoporous MnO₂ Nanospheres as Light Source-Free Carriers for Synergistic Starvation and Chemiexcited Photodynamic Tumor Therapy

Electron Transfer Strategies to Regulate Carriers’ Separation for Intensive Pyroelectric Dynamic Therapy With Simultaneous Photothermal Therapy

A Diode‐Like Dye‐Cu Anisotropic Junction in a Coordination Polymer as a Logic State Ratchet for Intratumor Redox Photomodulation

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A facile composite nanoparticle promoted by photoelectron transfer and consumption for tumor combination therapy

Abstract: Titanium dioxide nanoparticle is a promising agent for oxygen-independent Type I PDT. However, the low separation efficiency of electron-hole pairs limits its application. It is reported that the Cu2(OH)PO4 can...

Cited by 6 publications

References 45 publications

Hollow Mesoporous MnO2 Nanospheres as Light Source-Free Carriers for Synergistic Starvation and Chemiexcited Photodynamic Tumor Therapy

Hollow Mesoporous MnO2 Nanospheres as Light Source-Free Carriers for Synergistic Starvation and Chemiexcited Photodynamic Tumor Therapy

Electron Transfer Strategies to Regulate Carriers’ Separation for Intensive Pyroelectric Dynamic Therapy With Simultaneous Photothermal Therapy

A Diode‐Like Dye‐Cu Anisotropic Junction in a Coordination Polymer as a Logic State Ratchet for Intratumor Redox Photomodulation

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Product

Resources

About

Hollow Mesoporous MnO₂ Nanospheres as Light Source-Free Carriers for Synergistic Starvation and Chemiexcited Photodynamic Tumor Therapy

Hollow Mesoporous MnO₂ Nanospheres as Light Source-Free Carriers for Synergistic Starvation and Chemiexcited Photodynamic Tumor Therapy