A Facile Fabrication to Cellulose-based Nanoparticles with Thermo-responsivity and Carboxyl Functional Groups

Dou, Hongjing; Yang, Weihai; Kim, Sun

doi:10.1246/cl.2006.1374

Cited by 9 publications

(7 citation statements)

References 18 publications

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“…The synthesis of microgels follows our previous report, − which is based on the graft polymerization of AA from HPC at the presence of the bifunctional monomer MBA where the polymerization was initiated by CAN. An aqueous solution of 37 mg CAN in 1.25 mL of 0.1 mol/L nitric acid and 0.4 mL AA were successively added to 50 mL of 1.2 wt % aqueous solution of HPC under gentle stirring and nitrogen bubbling.…”

Section: Methodsmentioning

confidence: 99%

Thermal Sensitive Microgels with Stable and Reversible Photoluminescence Based on Covalently Bonded Quantum Dots

et al. 2010

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In this study, thermal sensitive microgels functionalized with carboxyl groups were synthesized directly from hydroxypropyl cellulose (HPC) and acrylic acid (AA) without using any organic solvent. Furthermore, covalently bonded hybrid microgels with novel thermosensitivity in terms of size and fluorescence were fabricated from these HPC-PAA microgels and cysteamine-capped CdTe quantum dots (QDs). The composition of the hybrid microgels were characterized by thermal thermogravimetric analysis (TGA) and coulometric titration. It was verified that the weight percent of CdTe QDs was ca. 40%, and the percent of poly(acrylic acid) varied between 9.0% and 13.6%. Through a systematic study, it was found that both the size and the fluorescent intensity of the microgels decreased as the temperature increased from below the lower critical solution temperature (LCST) to above the LCST of the HPC. Different from most reported cases, it was found that the thermal sensitive alteration of the current hybrid microgels' size and fluorescent intensity are reversible. The novel fluorescent properties are deduced to be related to the structural characteristics of the microgels, i.e., the QDs are covalently bonded to the microgels and the dispersion of QDs in the microgels is spatially homogeneous. As a consequence of this special structure, the refractive indexes of the microgels were changed and the surface defects of the QDs were reduced, and therefore affected the fluorescent properties of the resulting hybrid microgels.

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Section: Methodsmentioning

confidence: 99%

Thermal Sensitive Microgels with Stable and Reversible Photoluminescence Based on Covalently Bonded Quantum Dots

et al. 2010

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“…Moving away from dextran, thermoresponsive nanoparticles based on a temperature‐sensitive polysaccharide, hydroxypropyl cellulose (HPC), were fabricated via the GISA approach using AA as the monomer . HPC is a derivative of cellulose (Fig.…”

Section: Synthetic Strategies For Polysaccharide‐based Nanocarriersmentioning

confidence: 99%

Saccharide‐based nanocarriers for targeted therapeutic and diagnostic applications

Mukwaya

Wang

Dou

2018

Polymer International

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Many therapeutic and diagnostic agents suffer from short circulation times or poor selectivity resulting in the need for frequent drug administration and adverse side‐effects. On this basis, selective nanocarriers have been used to address most of the drawbacks via the encapsulation or conjugation of therapeutic and diagnostic agents to allow the targeted release of cargo to diseased sites or tumours, while maintaining low levels of cytotoxicity. Saccharides, which can be classified as monosaccharides, disaccharides and oligo/polysaccharides, have demonstrated great potential in the construction of nanocarriers, as well as the targeted guidance of the nanocarriers to diseased tissues. The fabrication of nanocarriers from natural materials such as polysaccharides affords biodegradability and biocompatibility, and in some instances confers targeting capabilities. The most recent progress in saccharide‐based targeted nanocarriers fabricated via facile one‐pot routes or complex two‐pot synthetic routes is reviewed here, with a particular focus on the high efficiency and flexibility of the one‐pot approach. In addition, inspired by the self‐assembly processes involving saccharides that occur in living organisms, particular emphasis is placed on disease‐targeting nanocarriers that are constructed from or modified by saccharides. © 2018 Society of Chemical Industry

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“…19 25 Such anomalous behavior was also reported by Dou et al who observed an increase in the size but only at temperatures around and higher than the LCST (41 C). 26 At temperatures greater than the LCST the hydrophilicity to hydrophobicity transition of HPC chains in water may induce self-association, leading to the formation of metastable nanoparticle aggregates. 19 25 26 Gao et al also reported that HPC chains may form different metastable aggregates depending on how the system is brought to that temperature.…”

Section: Tgamentioning

confidence: 99%

Magnetic Nanoparticles Encapsulated Within a Thermoresponsive Polymer

Gaharwar¹,

Je²,

Müller-Schulte³

et al. 2009

j nanosci nanotechnol

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This study describes a facile two-step approach to modify the surface of nanoparticles, thereby imparting a core-shell structure to the system. The core consists of magnetic nanoparticles and the shell is composed of thermoresponsive hydroxypropyl cellulose, using a coupling agent to covalently bind the core to the shell. Hydroxypropyl cellulose is known for its biocompatibility and biodegradability, and its thermoresponsive properties make it an excellent candidate for fabricating biocompatible stimuli-responsive magnetic nanoparticles. We report the synthesis of magnetic nanoparticles and the successful binding of the polymer to them. X-ray diffraction studies show that the surface modification of the magnetic nanoparticles does not result in any phase change and the size of the magnetic core thus calculated (7 nm) reveals that such hybrid core-shell system is superparamagnetic in nature, as further confirmed by magnetization measurements. The size obtained by X-ray diffraction is in good agreement with that obtained by transmission electron microscope. Evidence of binding is given by Fourier transform infrared spectroscopy and a quantitative analysis of the polymeric content obtained by thermogravimetry analysis. Dynamic light scattering as a function of temperature reveals the thermoresponsive behavior of the particles with a lower critical solution temperature around 41 degrees C, which is also the temperature at which cellulose undergoes a coil-to-globule transition.

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A Facile Fabrication to Cellulose-based Nanoparticles with Thermo-responsivity and Carboxyl Functional Groups

Cited by 9 publications

References 18 publications

Thermal Sensitive Microgels with Stable and Reversible Photoluminescence Based on Covalently Bonded Quantum Dots

Thermal Sensitive Microgels with Stable and Reversible Photoluminescence Based on Covalently Bonded Quantum Dots

Saccharide‐based nanocarriers for targeted therapeutic and diagnostic applications

Magnetic Nanoparticles Encapsulated Within a Thermoresponsive Polymer

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