A facile in situ synthesis of MIL-101-CdSe nanocomposites for ultrasensitive electrochemiluminescence detection of carcinoembryonic antigen

Li, Qiao; Yang, Ying; Liu, Xing-Pei; Wei, Yuping; Mao, Chang‐Jie; Niu, Helin; Song, Ji‐Ming; Zhang, Shengyi; Jin, Baokang; Jiang, Meng Dan

doi:10.1016/j.snb.2016.09.143

Cited by 43 publications

(13 citation statements)

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“…Metal–organic frameworks (MOFs) are porous hybrid materials with a periodic network structure composed of metal centers and organic ligands . With the features of high specific surface area, high porosity structure, tunable pore sizes, unsaturated metal sites, structural flexibility, outstanding optical properties [such as fluorescence (FL) and ECL], and easy to assemble, MOFs show considerable capabilities in energy storage, catalysis, analytical detection, environmental monitoring, drug delivery, and development of optical materials. − Moreover, with the high porosity structure, MOFs are widely used as carriers of proteins, small organic molecules, metal clusters, and semiconductor quantum dots by adsorption, encapsulation, deposition or surface functionalization, and so on. − Some ECL luminophores such as ruthenium complexes, ABEI, nanoclusters, and quantum dots have been assembled into MOFs. − However, these research studies only focused on the ECL behaviors of the abovementioned luminophores and MOF moieties were mainly used as supporting carriers and catalysts. Until now, the PRMCECL of MOFs encapsulating luminophores has not been reported.…”

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confidence: 99%

Potential-Resolved Differential Electrochemiluminescence Immunosensor for Cardiac Troponin I Based on MOF-5-Wrapped CdS Quantum Dot Nanoluminophores

et al. 2020

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Recently, nanoluminophores with the potentialresolved multicolor electrochemiluminescence (PRMCECL) property have emerged and shown promising applications in sensitive, selective, and accurate bioassays, bioimaging, and multicolor emitting devices. However, only limited PRMCECL nanoluminophores and their applications in ratiometric biosensors eliminating proportional errors have been reported. Herein, a novel PRMCECL nanoluminophore was synthesized by encapsulating CdS quantum dots (CdSQDs) into MOF-5 (CdSQDs@MOF-5). Using K 2 S 2 O 8 as a coreactant, two electrochemiluminescence (ECL) peaks, ECL-1 centered at 685 nm and ECL-2 centered at 475 nm, were observed at −1.4 and −1.8 V, respectively. Related ECL mechanisms have been proposed. Based on the potentialresolved ECL signals, a label-free differential ECL immunosensor for the determination of cardiac troponin I (cTnI) was established by assembly of poly(diallyldimethylammonium chloride), CdSQDs@MOF-5, and cTnI antibody-functionalized silver nanoparticles on the surface of the fluorine-doped tin oxide electrode subsequently. In the presence of cTnI, cTnI was captured by the sensing interface, leading to an increase in ECL-1 and ECL-2 intensity. cTnI could be determined in the range of 0.01−1000 pg/mL with a detection limit of 5.01 fg/mL using the intensity difference between ECL-1 and ECL-2. This work provides a new family member of PRMCECL nanoluminophores. The proposed label-free differential ECL immunosensor provides a new strategy based on potentialresolved ECL signals, which could effectively eliminate the additive error and show better sensitivity, selectivity, and accuracy for the detection of cTnI than the single-signal strategy and ratiometric strategy.

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confidence: 99%

Potential-Resolved Differential Electrochemiluminescence Immunosensor for Cardiac Troponin I Based on MOF-5-Wrapped CdS Quantum Dot Nanoluminophores

et al. 2020

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“…The obvious characteristic peaks in the XRD pattern of CdSe QDs (black curve) at 2θ angles of 26.05, 43.4, and 51.16°correspond to the (111), (220), and (311) planes, respectively, thus implying that CdSe QDs have good crystallinity. 30,39 The characteristic peaks of ZIF-8 (red curve) appear at 2θ = 7. 35, 10.40, 12.75, 14.73, 16.48, and 18.04°, corresponding to the lattice faces of ( 011), ( 002), ( 112), ( 022), (013), and (222), respectively, revealing that the obtained ZIF-8 has good crystallinity.…”

Section: Resultsmentioning

confidence: 99%

“…To indicate that CdSe QDs and ZIF-8 could be modified on the PAA membrane surface, XRD was utilized to characterize the prepared samples, as depicted in Figure l. The obvious characteristic peaks in the XRD pattern of CdSe QDs (black curve) at 2θ angles of 26.05, 43.4, and 51.16° correspond to the (111), (220), and (311) planes, respectively, thus implying that CdSe QDs have good crystallinity. , The characteristic peaks of ZIF-8 (red curve) appear at 2θ = 7.35, 10.40, 12.75, 14.73, 16.48, and 18.04°, corresponding to the lattice faces of (011), (002), (112), (022), (013), and (222), respectively, revealing that the obtained ZIF-8 has good crystallinity. ,− Compared to the PAA membrane (blue line), the XRD pattern (pink line) of the clearly characteristic peaks of the CdSe@ZIF-8/PAA membrane indicates that the PAA membrane surface is covered by CdSe QDs and ZIF-8.…”

Section: Results and Discussionmentioning

confidence: 99%

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In Situ Growth Visualization Nanochannel Membrane for Ultrasensitive Copper Ion Detection under the Electric Field Enrichment

Gao

Sun

et al. 2020

ACS Appl. Mater. Interfaces

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The transport of ionic species through nanochannels plays an important role in the basic research and practical application of nanofluidic devices. Here, a visualized CdSe@ZIF-8/PAA nanochannel membrane was created by employing in situ growth of zeolite imidazole skeleton (ZIF-8) and CdSe quantum dots (CdSe QDs) on a porous anodized aluminum oxide (PAA) membrane surface using CdSe QDs, 2-methylimidazole, and zinc nitrate as the precursor solvents. ZIF-8 is a kind of metal−organic framework, a microporous material that possesses strong metal adsorption capacity. In addition, CdSe quantum dots have fluorescent properties. The nanochannel membrane detects copper ions (Cu 2+ ) by quenching the fluorescence intensity by the interaction between Cu 2+ and Se and S atoms. The direct potential of 5 V was applied to achieve Cu 2+ enrichment at the nanochannel interface, and the fluorescence change was observed. The CdSe@ ZIF-8/PAA nanochannel membrane has a good linear range of concentration (0.01 pM−1 μM) for Cu 2+ detection. With the help of nanochannel enrichment, its detection limit reaches 4 fM. In addition, this nanochannel membrane has good selectivity for Cu 2+ .

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“…Although MOFs have a high porosity and a tunable pore size, the pore size could be fixed along with the successful preparation of MOFs. Most classical MOFs contain only micropores, which leads to the inability of guest luminophores to easily enter the MOF interior through the pores, making the luminophore loading capacity of MOF materials greatly be reduced [ 75 ]. To solve this problem, Yang et al wrapped the luminescence inside the MOF material by an in situ synthesis method during the MOF growth process, which resulted in a greatly enhanced loading capacity of the guest luminescence, and thus prepared the nanocomposite with a high-intensity ECL response [ 47 ].…”

Section: Synthesis Of Porous Nanomaterials With Ecl Propertiesmentioning

confidence: 99%

Progress and Prospects of Electrochemiluminescence Biosensors Based on Porous Nanomaterials

Yang

et al. 2022

Biosensors

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Porous nanomaterials have attracted much attention in the field of electrochemiluminescence (ECL) analysis research because of their large specific surface area, high porosity, possession of multiple functional groups, and ease of modification. Porous nanomaterials can not only serve as good carriers for loading ECL luminophores to prepare nanomaterials with excellent luminescence properties, but they also have a good electrical conductivity to facilitate charge transfer and substance exchange between electrode surfaces and solutions. In particular, some porous nanomaterials with special functional groups or centered on metals even possess excellent catalytic properties that can enhance the ECL response of the system. ECL composites prepared based on porous nanomaterials have a wide range of applications in the field of ECL biosensors due to their extraordinary ECL response. In this paper, we reviewed recent research advances in various porous nanomaterials commonly used to fabricate ECL biosensors, such as ordered mesoporous silica (OMS), metal–organic frameworks (MOFs), covalent organic frameworks (COFs) and metal–polydopamine frameworks (MPFs). Their applications in the detection of heavy metal ions, small molecules, proteins and nucleic acids are also summarized. The challenges and prospects of constructing ECL biosensors based on porous nanomaterials are further discussed. We hope that this review will provide the reader with a comprehensive understanding of the development of porous nanomaterial-based ECL systems in analytical biosensors and materials science.

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A facile in situ synthesis of MIL-101-CdSe nanocomposites for ultrasensitive electrochemiluminescence detection of carcinoembryonic antigen

Cited by 43 publications

References 28 publications

Potential-Resolved Differential Electrochemiluminescence Immunosensor for Cardiac Troponin I Based on MOF-5-Wrapped CdS Quantum Dot Nanoluminophores

Potential-Resolved Differential Electrochemiluminescence Immunosensor for Cardiac Troponin I Based on MOF-5-Wrapped CdS Quantum Dot Nanoluminophores

In Situ Growth Visualization Nanochannel Membrane for Ultrasensitive Copper Ion Detection under the Electric Field Enrichment

Progress and Prospects of Electrochemiluminescence Biosensors Based on Porous Nanomaterials

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