A facile method for the controlled polymerization of biocompatible and thermoresponsive oligo(ethylene glycol) methyl ether methacrylate copolymers

Alejo, Teresa; Prieto, Martín; García‐Juan, Hugo; Andreu, Vanesa; Mendoza, Gracia; Sebastián, Víctor; Arruebo, Manuel

doi:10.1038/s41428-017-0004-8

Cited by 19 publications

(19 citation statements)

References 51 publications

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“…Given that the effect of nanoparticles on cell cycle progression, apoptosis or necrosis may depend on the nature of the thermoresponsive polymer coating in the surface of gold nanoparticles. It is important to mention that OEGMA-based copolymers have been reported as non-cytotoxic at the highest concentration tested (i.e., 0.4 mg/mL) [46].…”

Section: Cell Viability Assaymentioning

confidence: 95%

“…The loading and the release profiles of the local anesthetic bupivacaine were determined to study the nanoparticles efficiency and the effect of the light/temperature stimuli in the release process. LCST within the physiological temperature [46]. The final product was purified by passing the ethanolic solution containing the resulting polymer through a silica gel (60-120 mesh) column.…”

Section: Introductionmentioning

confidence: 99%

“…OEGMA 500 ] monomer molar ratio used was 88/12, to maintain the LCST in the physiological range[46]. After purging, the solution was heated to 65 ºC, and the polymerization was initiated by the addition of APS (450 μL, 0.035 M).…”

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confidence: 99%

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Controlled release of bupivacaine using hybrid thermoresponsive nanoparticles activated via photothermal heating

Alejo

Andreu

Mendoza

et al. 2018

Journal of Colloid and Interface Science

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Near-infrared (NIR) responsive nanoparticles are of great interest in the biomedical field as antennas for photothermal therapy and also as triggers for on-demand drug delivery. The present work reports the preparation of hollow gold nanoparticles (HGNPs) with plasmonic absorption in the NIR region covalently bound to a thermoresponsive polymeric shell that can be used as an on-demand drug delivery system for the release of analgesic drugs. The photothermal heating induced by the nanoparticles is able to produce the collapse of the polymeric shell thus generating the release of the local anesthetic bupivacaine in a spatiotemporally controlled way. Those HGNPs contain a 10 wt.% of polymer and present excellent reversible heating under NIR light excitation. Bupivacaine released at physiological temperature (37 °C) showed a pseudo-zero order release that could be spatiotemporally modified on-demand after applying several pulses of light/temperature above and below the lower critical solution temperature (LCST) of the polymeric shell. Furthermore, the nanomaterials obtained did not displayed detrimental effects on four mammalian cell lines at doses up to 0.2 mg/mL. From the results obtained it can be concluded than this type of hybrid thermoresponsive nanoparticle can be used as an externally activated on-demand drug delivery system.

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Section: Cell Viability Assaymentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

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Controlled release of bupivacaine using hybrid thermoresponsive nanoparticles activated via photothermal heating

Alejo

Andreu

Mendoza

et al. 2018

Journal of Colloid and Interface Science

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“…Lutz et al synthesized copolymers of MEO2MA and OEGMA via atom transfer radical polymerization and observed possible control of LCST between 26 and 90 °C by altering the monomer compositions [ 152 ]. Consequently, a large number of different types of polymers [ 153 , 154 , 155 ], micelles [ 156 , 157 ], vesicles [ 158 ], micro/nanogels [ 159 ], and smart POEGMA-based hydrogels [ 160 ] have been synthesized and investigated.…”

Section: Thermosensitive Polymersmentioning

confidence: 99%

Thermoresponsive Nanogels Based on Different Polymeric Moieties for Biomedical Applications

Ghaeini-Hesaroeiye

Bagtash

Boddohi

et al. 2020

Gels

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Nanogels, or nanostructured hydrogels, are one of the most interesting materials in biomedical engineering. Nanogels are widely used in medical applications, such as in cancer therapy, targeted delivery of proteins, genes and DNAs, and scaffolds in tissue regeneration. One salient feature of nanogels is their tunable responsiveness to external stimuli. In this review, thermosensitive nanogels are discussed, with a focus on moieties in their chemical structure which are responsible for thermosensitivity. These thermosensitive moieties can be classified into four groups, namely, polymers bearing amide groups, ether groups, vinyl ether groups and hydrophilic polymers bearing hydrophobic groups. These novel thermoresponsive nanogels provide effective drug delivery systems and tissue regeneration constructs for treating patients in many clinical applications, such as targeted, sustained and controlled release.

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“…However, thermoresponsive polymers are completely soluble in the solvent in all proportions at temperatures below the lower critical solution temperature (LCST) and become insoluble above the LCST. The thermosensitive micelles mainly consist of N -isopropylacryl amide (NIPAM) [ 90 , 94 , 95 , 96 ], propylene glycol [ 67 , 97 ], ε-caprolactone [ 98 , 99 , 100 ], and oligo(ethylene glycol) methacrylate (OEGMA) [ 101 , 102 , 103 ].…”

Section: Mechanisms Of Self-assembly Of Poss-based Amphiphilic Copmentioning

confidence: 99%

Self-Assembly and Applications of Amphiphilic Hybrid POSS Copolymers

et al. 2018

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Understanding the mechanism of molecular self-assembly to form well-organized nanostructures is essential in the field of supramolecular chemistry. Particularly, amphiphilic copolymers incorporated with polyhedral oligomeric silsesquioxanes (POSSs) have been one of the most promising materials in material science, engineering, and biomedical fields. In this review, new ideas and research works which have been carried out over the last several years in this relatively new area with a main focus on their mechanism in self-assembly and applications are discussed. In addition, insights into the unique role of POSSs in synthesis, microphase separation, and confined size were encompassed. Finally, perspectives and challenges related to the further advancement of POSS-based amphiphilics are discussed, followed by the proposed design considerations to address the challenges that we may face in the future.

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A facile method for the controlled polymerization of biocompatible and thermoresponsive oligo(ethylene glycol) methyl ether methacrylate copolymers

Cited by 19 publications

References 51 publications

Controlled release of bupivacaine using hybrid thermoresponsive nanoparticles activated via photothermal heating

Controlled release of bupivacaine using hybrid thermoresponsive nanoparticles activated via photothermal heating

Thermoresponsive Nanogels Based on Different Polymeric Moieties for Biomedical Applications

Self-Assembly and Applications of Amphiphilic Hybrid POSS Copolymers

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