A facile one-pot method to two kinds of graphene oxide-based hydrogels with broad-spectrum antimicrobial properties

Wang, Xinpeng; Liu, Zhiming; Ye, Xiangping; Hu, Kun; Zhong, Huiqing; Yuan, Xiaochan; Xiong, Honglian; Guo, Zhouyi

doi:10.1016/j.cej.2014.08.102

Cited by 51 publications

(24 citation statements)

References 32 publications

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“…Moreover, GO has a 2D planar structure with a high specific area which can introduce interactions with the polymer matrix. Recent studies have demonstrated that GO is a biocompatible material, and has antibacterial ability with mild cytotoxicity [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. The antibacterial activity of graphene and graphene derivatives is found to involve membrane puncture [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

“…Different antibacterial organic compounds and polymers were used to functionalize graphene-family materials in order to enhance the antibacterial activity of the resulting composites. Based on this strategy, CS, ramizol, benzalkonium bromide (BKB) and polyhexamethylene guanidine hydrochloride (PHGC) were all applied to obtain novel antibacterial agents with remarkable antibacterial activity [ 14 , 20 , 38 , 39 , 40 ]. Compared with low molecular organic compounds, antibacterial polymers typically show prolonged lifetimes, reduced residual toxicity and enhanced antibacterial activity.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Characterization, and Bactericidal Evaluation of Chitosan/Guanidine Functionalized Graphene Oxide Composites

Gao

Sun

et al. 2016

Molecules

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In response to the wide spread of microbial contamination induced by bacterial pathogens, the development of novel materials with excellent antibacterial activity is of great interest. In this study, novel antibacterial chitosan (CS) and polyhexamethylene guanidine hydrochloride (PHGC) dual-polymer-functionalized graphene oxide (GO) (GO-CS-PHGC) composites were designed and easily fabricated. The as-prepared materials were characterized by Fourier transform infrared (FTIR), X-ray photoelectron spectrometer (XPS), field emission scanning electron microscopy (FE-SEM), transmission electron microscope (TEM), thermogravimetric analysis (TGA) and Raman spectroscopy. Their antibacterial capability towards bacterial strains was also studied by incubating both Gram-negative bacteria and Gram-positive bacteria in their presence. More significantly, the synergistic antibacterial action of the three components was assayed, and the findings implied that the as-prepared GO-CS-PHGC shows enhanced antibacterial activity when compared to its single components (GO, CS, PHGC or CS-PHGC) and the mixture of individual components. Not only Gram-negative bacteria but also Gram-positive bacteria are greatly inhibited by GO-CS-PHGC composites. The minimum inhibitory concentration (MIC) value of GO-CS-PHGC against E. coli was 32 μg/mL. With the powerful antibacterial activity as well as its low cost and facile preparation, GO-CS-PHGC has potential applications as a novel antibacterial agent in a wide range of biomedical uses.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Bactericidal Evaluation of Chitosan/Guanidine Functionalized Graphene Oxide Composites

Gao

Sun

et al. 2016

Molecules

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“…In addition, their group has also investigated some bacteria bioactivity and interaction with environment by aggregated graphene nanosheets as encapsulating material and effective photothermal agent 6 . On the other hand, as an attractive class of soft material, there is considerable interest in assembling graphene and its derivatives into 3D porous gels with ultralow density, high compressibility, high conductivity, large surface areas and strong mechanical strength 7 8 9 10 11 12 13 14 . In addition, the GO-based hydrogels have been obtained by adding polymers, macromolecules, small organic molecules, or cation compounds into the aqueous dispersion of GO 15 16 17 18 .…”

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confidence: 99%

Reduced Graphene Oxide-Based Silver Nanoparticle-Containing Composite Hydrogel as Highly Efficient Dye Catalysts for Wastewater Treatment

Jiao

Guo

Zhang

et al. 2015

Sci Rep

191

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New reduced graphene oxide-based silver nanoparticle-containing composite hydrogels were successfully prepared in situ through the simultaneous reduction of GO and noble metal precursors within the GO gel matrix. The as-formed hydrogels are composed of a network structure of cross-linked nanosheets. The reported method is based on the in situ co-reduction of GO and silver acetate within the hydrogel matrix to form RGO-based composite gel. The stabilization of silver nanoparticles was also achieved simultaneously within the gel composite system. The as-formed silver nanoparticles were found to be homogeneously and uniformly dispersed on the surface of the RGO nanosheets within the composite gel. More importantly, this RGO-based silver nanoparticle-containing composite hydrogel matrix acts as a potential catalyst for removing organic dye pollutants from an aqueous environment. Interestingly, the as-prepared catalytic composite matrix structure can be conveniently separated from an aqueous environment after the reaction, suggesting the potentially large-scale applications of the reduced graphene oxide-based nanoparticle-containing composite hydrogels for organic dye removal and wastewater treatment.

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“…Studies on graphene and graphene-based materials has found their use in medicine and life sciences which includes imaging [9], biosensors [10,11], drug delivery [12][13][14] and pathogen control [15,16]. The response of using graphene oxide on microorganisms has been studied extensively.…”

Section: Introductionmentioning

confidence: 99%

“…There is a need to develop more safe and cost-effective biocidal materials. Nanosized particles either simple or composite by nature, exhibit unique physical and chemical properties and shows a potential of being used in various biomedical applications [7,8].Studies on graphene and graphene-based materials has found their use in medicine and life sciences which includes imaging [9], biosensors [10,11], drug delivery [12][13][14] and pathogen control [15,16]. The response of using graphene oxide on microorganisms has been studied extensively.…”

mentioning

confidence: 99%

Synthesis, Characterization and Antibacterial Study of Copper Oxide-Graphene Nanocomposites

Kumar¹,

Manisha²

2017

Asian J. Chem.

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INTRODUCTIONMicrobial infections are one of the major causes of serious health issues due to the development of antibiotic-resistant strains of bacteria [1]. Nanomaterials have been found to have promising medicinal applications. The synthesis of compatible nanosized drug particles having specific size, shape and physical and chemical properties is of huge importance in the genesis of new pharmaceutical products [2][3][4][5][6]. There is a need to develop more safe and cost-effective biocidal materials. Nanosized particles either simple or composite by nature, exhibit unique physical and chemical properties and shows a potential of being used in various biomedical applications [7,8].Studies on graphene and graphene-based materials has found their use in medicine and life sciences which includes imaging [9], biosensors [10,11], drug delivery [12][13][14] and pathogen control [15,16]. The response of using graphene oxide on microorganisms has been studied extensively. However, the satisfactory results of metal oxide and graphene oxide nanocomposites have not been reported so far [17][18][19][20][21].In continuation to our earlier studies [22][23][24][25][26][27][28], in present study, we have focused on the synthesis of CuO nanoparticles by facile and cost effective sol-gel method and nanocomposite of copper were prepared with reduced graphene oxide. Antibacterial properties of the synthesized nanoparticles and nano- composites were investigated against Gram-positive and Gramnegative bacteria. The aim of this study is to synthesize nanocomposite material with better or comparable antibacterial performance. EXPERIMENTALAll the chemicals used were of analytical reagent grade and used without further purification. Chemicals used were graphite powder (< 20 µ), Cu(NO 3 )·3H 2 O, NaNO 3 , H 2 O 2 , H 2 SO 4 , KMnO 4 , HCl, NaOH, NaBH 4 , citric acid and ethylene glycol. The strains employed in this work were the Gram-negative bacterium (E. coli) and the Gram-positive bacterium (S. epidermidis). In addition, nutrient broth and agar-agar were used to prepare agar plates.Preparation of reduced graphene oxide: Graphene oxide (GO) was synthesized from graphite powder by a modified Hummers method [29]. Graphite powder, NaNO 3 and H 2 SO 4 were mixed together at 0 °C. Then, KMnO 4 was added slowly into the reaction mixture with constant stirring. The mixture was heated to 35 °C and stirred for 12 h and then double distilled water was added slowly under vigorous stirring. Hydrogen peroxide solution was added to reduce the residual MnO 2 . The resultant was then washed by acidified water (3 %) and then with double distilled water three times followed by filtration and drying. Reduced graphene oxide sheets were then obtained.

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A facile one-pot method to two kinds of graphene oxide-based hydrogels with broad-spectrum antimicrobial properties

Cited by 51 publications

References 32 publications

Synthesis, Characterization, and Bactericidal Evaluation of Chitosan/Guanidine Functionalized Graphene Oxide Composites

Synthesis, Characterization, and Bactericidal Evaluation of Chitosan/Guanidine Functionalized Graphene Oxide Composites

Reduced Graphene Oxide-Based Silver Nanoparticle-Containing Composite Hydrogel as Highly Efficient Dye Catalysts for Wastewater Treatment

Synthesis, Characterization and Antibacterial Study of Copper Oxide-Graphene Nanocomposites

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