A facile preparation of Au—SiO2 nanocomposite for simultaneous electrochemical detection of dopamine and uric acid

Immanuel, Susan; Aparna, T.K.; Sivasubramanian, R.

doi:10.1016/j.surfin.2018.11.010

Cited by 74 publications

(17 citation statements)

References 46 publications

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“…Sensitivity is vital for detecting molecules such as neurotransmitters that are available at very low concentrations within the human body (dopamine: < 10 À 6 M). [240] In such cases, doped graphene or graphene nanocomposites can come in handy. Integration of graphene with other nanomaterials like metals, [240] metal oxides [242] and conductive polymers [243] could richly provide prospects for the development of sensor platforms with enhanced electrocatalytic performance.…”

Section: Biosensorsmentioning

confidence: 99%

“…So far, compared to other nanomaterials, [239] CRGO could not provide a very low detection of Epi or certainly any other biomolecules [100,101] as it lacked sensitivity. Sensitivity is vital for detecting molecules such as neurotransmitters that are available at very low concentrations within the human body (dopamine: <10 −6 M) [240] . In such cases, doped graphene or graphene nanocomposites can come in handy.…”

Section: Applicationsmentioning

confidence: 99%

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Progress and Prospects on the Fabrication of Graphene‐Based Nanostructures for Energy Storage, Energy Conversion and Biomedical Applications

Immanuel

Dar

Sivasubramanian

et al. 2021

Chemistry An Asian Journal

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Graphene, a two-dimensional (2D) layered material has attracted much attention from the scientific community due to its exceptional electrical, thermal, mechanical, biological and optical properties. Hence, numerous applications utilizing graphene-based materials could be conceived in next-generation electronics, chemical and biological sensing, energy conversion and storage, and beyond. The interaction between graphene surfaces with other materials plays a vital role in influencing its properties than other bulk materials. In this review, we outline the recent progress in the production of graphene and related 2D materials, and their uses in energy conversion (solar cells, fuel cells), energy storage (batteries, supercapacitors) and biomedical applications.

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Section: Biosensorsmentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

Progress and Prospects on the Fabrication of Graphene‐Based Nanostructures for Energy Storage, Energy Conversion and Biomedical Applications

Immanuel

Dar

Sivasubramanian

et al. 2021

Chemistry An Asian Journal

Self Cite

View full text Add to dashboard Cite

show abstract

“…Differential pulse voltammetry measurements enabled the determination of two linear ranges from 10–100 μM and 200–500 μM with a LOD of 1.98 μM for DA and a linear range from 10–500 μM with a LOD of 2.58 μM for UA. Further, the detection of DA and UA in serum sample analysis was performed successfully with satisfactory recovery values [95].…”

Section: Non-enzymatic Electrochemical Sensorsmentioning

confidence: 99%

Latest Trends in Electrochemical Sensors for Neurotransmitters: A Review

Tavakolian-Ardakani

Hosu

Cristea

et al. 2019

Sensors

117

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Neurotransmitters are endogenous chemical messengers which play an important role in many of the brain functions, abnormal levels being correlated with physical, psychotic and neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's disease. Therefore, their sensitive and robust detection is of great clinical significance. Electrochemical methods have been intensively used in the last decades for neurotransmitter detection, outclassing more complicated analytical techniques such as conventional spectrophotometry, chromatography, fluorescence, flow injection, and capillary electrophoresis. In this manuscript, the most successful and promising electrochemical enzyme-free and enzymatic sensors for neurotransmitter detection are reviewed. Focusing on the activity of worldwide researchers mainly during the last ten years (2010–2019), without pretending to be exhaustive, we present an overview of the progress made in sensing strategies during this time. Particular emphasis is placed on nanostructured-based sensors, which show a substantial improvement of the analytical performances. This review also examines the progress made in biosensors for neurotransmitter measurements in vitro, in vivo and ex vivo.

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“…On the other hand, UA is the primary final product of purine metabolism. The normal level of UA is between 2.4×10 −4 and 5.2×10 −4 mol L −1 in serum . Additionally, AA is an important vitamin in the human diet and very popular because of its antioxidant properties in foodstuffs, and AA concentration is 100 to 1000 times higher than DA .…”

Section: Introductionmentioning

confidence: 99%

Selective Electrochemical Determination of Dopamine with Molecularly Imprinted Poly(Carbazole‐co‐Aniline) Electrode Decorated with Gold Nanoparticles

et al. 2019

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Dopamine (DA) is a significant neurotransmitter in the central nervous system, coexisting with uric acid (UA) and ascorbic acid (AA). UA and AA are easily oxidizable compounds having potentials close to that of DA for electrochemical analysis, resulting in overlapping voltammetric response. In this work, a novel molecularly imprinted (MI) electrochemical sensor was proposed for selective determination of DA (in the presence of up to 80‐fold excess of UA and AA), relying on gold nanoparticles (Aunano)‐decorated glassy carbon (GC) electrode coated with poly(carbazole (Cz)‐co‐aniline (ANI)) copolymer film incorporating DA as template (DA imprinted‐GC/P(Cz‐co‐ANI)‐Aunano electrode, DA‐MIP‐Aunano electrode). The DA recognizing sensor electrode showed great electroactivity for analyte oxidation in 0.2 mol L−1 pH 7 phosphate buffer. Square wave voltammetry (SWV) was performed within 10−4–10−5 mol L−1 of DA, of which the oxidation peak potential was observed at 0.16 V. The limit of detection (LOD) and limit of quantification (LOQ) were 2.0×10−6 and 6.7×10−6 mol L−1, respectively. Binary and ternary synthetic mixtures of DA‐UA, DA‐AA and DA‐UA‐AA yielded excellent recoveries for DA. Additionally, DA was quantitatively recovered from a real sample of bovine serum spiked with DA, and determined in concentrated dopamine injection solution. The developed SWV method was statistically validated against a literature potentiodynamic method using a caffeic acid modified‐GC electrode.

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A facile preparation of Au—SiO2 nanocomposite for simultaneous electrochemical detection of dopamine and uric acid

Cited by 74 publications

References 46 publications

Progress and Prospects on the Fabrication of Graphene‐Based Nanostructures for Energy Storage, Energy Conversion and Biomedical Applications

Progress and Prospects on the Fabrication of Graphene‐Based Nanostructures for Energy Storage, Energy Conversion and Biomedical Applications

Latest Trends in Electrochemical Sensors for Neurotransmitters: A Review

Selective Electrochemical Determination of Dopamine with Molecularly Imprinted Poly(Carbazole‐co‐Aniline) Electrode Decorated with Gold Nanoparticles

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