A facile pseudo three component reaction for the synthesis of benzo [4,5]imidazo[1,2-a]pyridine derivatives

Abstract

Background: Benzo[4,5]imidazo[1,2-a]pyridine derivatives were accessed through an efficient pseudo three component reaction between dialdehydes such as o-phthalaldehyde, glutaraldehyde, 2,3-thiophenedicarboxaldehyde and the active methylene 2-(1H-benzo[d]imidazol-2-yl)acetonitrile. The products were obtained in a one-pot manner with easy purification and further characterized by NMR, FT-IR and HRMS spectral data (Figure 1).. Figure 1 Benzo [4,5]imidazo[1,2-a]pyridine. Citation: Vasuki G, Nithya N. A facile pseudo three component reaction for the synthesis of benzo [4,5]imidazo[1,2-a]pyridine derivatives. MOJ Biorg Org Chem.