2022
DOI: 10.1002/jbm.a.37458
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A facile 3D bio‐fabrication of customized tubular scaffolds using solvent‐based extrusion printing for tissue‐engineered tracheal grafts

Abstract: Tracheal implantation remains a major therapeutic challenge due to the unavailability of donors and the lack of biomimetic tubular grafts. Fabrication of biomimetic tracheal scaffolds of suitable materials with matched rigidity, enhanced flexibility and biocompatibility has been a major challenge in the field of tracheal reconstruction. In this study, customized tubular grafts made up of FDA-approved polycaprolactone (PCL) and polyurethane (PU) were fabricated using a novel solvent-based extrusion 3D printing.… Show more

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Cited by 8 publications
(2 citation statements)
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“…Over time, a wide variety of resorbable materials has been tested with the aim of mimicking native tissues as much as possible; among them, the most common are polycaprolactone (PCL) and polyurethane (PU). These two polymers can be combined in order to modulate the elastic properties and the degradation rate of the scaffold [23].…”
Section: Scaffold Optionsmentioning
confidence: 99%
See 1 more Smart Citation
“…Over time, a wide variety of resorbable materials has been tested with the aim of mimicking native tissues as much as possible; among them, the most common are polycaprolactone (PCL) and polyurethane (PU). These two polymers can be combined in order to modulate the elastic properties and the degradation rate of the scaffold [23].…”
Section: Scaffold Optionsmentioning
confidence: 99%
“…Lastly, a scaffold may be composed of multiple layers, where natural and synthetic tissues can be combined in order to overcome their respective limitations; these are referred to as hybrid scaffolds. An example is provided by the study of Ghorbani et al, who fabricated a scaffold whose outer layer was constituted by electrospun nanofibers composed of a blend of collagen and polycaprolactone (PCL), while the inner layer was made of decellularized aorta [23]. By doing so, the authors achieved a TE construct whose inner layer was biocompatible in order to avoid the formation of granulation tissue and favor epithelial cell ingrowth, while the outer layer had optimal mechanical and degradation properties.…”
Section: Scaffold Optionsmentioning
confidence: 99%