A facile strategy for fine-tuning the drug release efficacy of poly-L-lactic acid-polycaprolactone coatings by liquid flame spray

Pan, Yu; Zhou, Daofeng; Cui, Tingting; Zhang, Y. S.; Ye, Lei; Tian, Yuan; Zhou, Peng; Liu, Yi; Saitoh, Hidetoshi; Zhang, Bo-Tao; Li, Hua

doi:10.1016/j.porgcoat.2023.107807

Cited by 1 publication

(1 citation statement)

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“…The thermal spray processes for polymer coating production include flame spraying, high-velocity oxygen fuel (HVOF)/high-velocity air fuel (HVAF), plasma spraying, and cold spraying [ 26 ]. Coating biodegradable polymers by flame spraying is a widely used method, with advantages including low cost, simplicity, and environmental friendliness [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

A pH-Responsive Polycaprolactone–Copper Peroxide Composite Coating Fabricated via Suspension Flame Spraying for Antimicrobial Applications

Cui,

Zhou,

Zhang

et al. 2024

Materials

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In this study, a pH-responsive polycaprolactone (PCL)–copper peroxide (CuO2) composite antibacterial coating was developed by suspension flame spraying. The successful synthesis of CuO2 nanoparticles and fabrication of the PCL-CuO2 composite coatings were confirmed by microstructural and chemical analysis. The composite coatings were structurally homogeneous, with the chemical properties of PCL well maintained. The acidic environment was found to effectively accelerate the dissociation of CuO2, allowing the simultaneous release of Cu2+ and H2O2. Antimicrobial tests clearly revealed the enhanced antibacterial properties of the PCL-CuO2 composite coating against both Escherichia coli and Staphylococcus aureus under acidic conditions, with a bactericidal effect of over 99.99%. This study presents a promising approach for constructing pH-responsive antimicrobial coatings for biomedical applications.

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Section: Introductionmentioning

confidence: 99%