A facile synthesis of potent antiherpes drug substance, ganciclovir, 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine, using a new masked glycerol derivative

Raju, V. V. N. K. V. Prasada; Ravindra, Vedantham; Kamath, Suchitra S.; Mathad, Vijayavitthal T.; Dubey, P. K.; Reddy, Padi Pratap

doi:10.3998/ark.5550190.0010.c26

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2024

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Cited by 3 publications

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Efficient one-pot process for synthesis of antiviral drug Ganciclovir

Sudrik,

Karpe,

Jadhav

et al. 2024

J Chem Sci

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Efficient one-pot process for synthesis of antiviral drug Ganciclovir

Sudrik,

Karpe,

Jadhav

et al. 2024

J Chem Sci

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Ganciclovir

Al-Badr

Ajarim

2018

Profiles of Drug Substances, Excipients and Related Methodology

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Ganciclovir is synthetic nucleoside analog of guanine closely related to acyclovir but has greater activity against cytomegalovirus. This comprehensive profile on ganciclovir starts with a description of the drug: nomenclature, formulae, chemical structure, elemental composition, and appearance. The uses and application of the drug are explained. The methods that were used for the preparation of ganciclovir are described and their respective schemes are outlined. The methods which were used for the physical characterization of the dug are: ionization constant, solubility, X-ray powder diffraction pattern, crystal structure, melting point, and differential scanning calorimetry. The chapter contains the spectra of the drug: ultraviolet spectrum, vibrational spectrum, nuclear magnetic resonance spectra, and the mass spectrum. The compendial methods of analysis of ganciclovir include the United States Pharmacopeia methods. Other methods of analysis that were reported in the literature include: high-performance liquid chromatography alone or with mass spectrometry, electrophoresis, spectrophotometry, voltammetry, chemiluminescence, and radioimmunoassay. Biological investigation on the drug includes: pharmacokinetics, metabolism, bioavailability, and biological analysis. Reviews on the methods used for preparation or for analysis of the drug are provided. The stability of the drug in various media and storage conditions is reported. More than 240 references are listed at the end of the chapter.

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Trifluoroacetic acid: Uses and recent applications in organic synthesis

López

Salazar

2013

Journal of Fluorine Chemistry

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A facile synthesis of potent antiherpes drug substance, ganciclovir, 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine, using a new masked glycerol derivative

Cited by 3 publications

References 9 publications

Efficient one-pot process for synthesis of antiviral drug Ganciclovir

Efficient one-pot process for synthesis of antiviral drug Ganciclovir

Ganciclovir

Trifluoroacetic acid: Uses and recent applications in organic synthesis

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