A Facile Synthesis of [Tetrahydrofuran‐³H] Terazosin

Abstract

An efficient synthesis of [ 3 H] terazosin at high specific activity from prazosin is described.

Tritium NMR: A compilation of data and a practical guide

“…A number of more cases of tritium incorporation into biologically active compounds performed during this period (2000-2015) was studied by Filer and coworkers by means of tritium NMR, as was exemplified with tritium NMR study of [tetrahydrofuran-3 H] terazosin, [76] an efficient synthesis of the ace inhibitor [phenyl-3 H] lisinopril, [77] synthesis of [ 3 H] dapsone, [78] synthesis of [ring-3 H] dopamine and its fluoro analogues, [79] tritiation of CEP-1347, a semisynthetic derivative of the indolocarbazole natural product, [80] structural study of biologically active equine estrogens and sulfate conjugates labeled with tritium, [81] and tritium labeling of insect neurotransmitter and TAAR1 agonist (±)-octopamine. [82] In the beginning of this century, Vogt and coauthors [83] introduced two alternative heterocorrelated pulse sequences for the 1 H-3 H spin systems, which were shown to have an advantage over earlier methods.…”