A facile three‐components, one‐pot synthesis of pyrimido[4,5‐d]pyrimidine‐2,5‐dione derivatives under microwave‐assisted conditions

Abstract

Pyrimido[4,5‐d]pyrimidine‐2,5‐dione derivatives have been synthesized in high yields in a novel, onepot, and efficient process by condensation of 6‐amino‐3‐methyl‐2‐(methylthio)pyrimidin‐4(3H)‐one, aldehydes and urea under microwave‐assisted conditions.

A Clean Synthesis of Spiro[indoline-3,9'-xanthene]trione Derivatives

“…11,12) The other useful applications of these heterocycles are as dyes, fluorescent materials for visualization of biomolecules, and in laser technologies. 13,14) As part of our program aimed at developing new selective and environmentally-friendly methodologies for the preparation of heterocyclic compounds, [15][16][17][18][19][20][21] we performed the synthesis of spiro[indoline-3,9Ј-xanthene]triones through a cyclo-condensation reaction employing water as the reaction medium. In fact, as clearly stated by R. A. Sheldon, it is generally recognized that "the best solvent is no solvent and if a solvent (diluent) is needed it should preferably be water."…”

A new paradigm for designing ring construction strategies for green organic synthesis: implications for the discovery of multicomponent reactions to build molecules containing a single ring

“…Scheme 11 shows the following literature examples of [3 + 2 + 1] cycloadditions following novel mappings (blue structures shown in Fig. 9): Dabiri [189–190], and Singh [191]. The Yi [192] example follows the traditional coupling using a nitrile instead of a urea precursor, which ultimately leads to a heterocyclic ring that contains only one nitrogen atom instead of two.…”

Synthesis and Characterization of Fully Substituted Pyrimidines by Using Ketene Dithioacetal as Potent Antimicrobial Agent

“…The Biginelli reaction [7] has been reported for the synthesis of many pyrimidine darivatives by the one-pot condensation of active methylene, urea and aldehydes. There are some other methods are also reported with some little modification in Biginelli reaction by the condensation of aldehydes, urea and arylketones in acetic acid using a catalytic amount of KHSO4 [8], in basic condition [9] and by microwave irradiation [10]. Now a days of literature have been reported for the synthesis of thiophene, furan, isooxazole, pyrazole, pyridine and pyrimidine etc.…”