1994
DOI: 10.1016/s0169-6009(08)80163-8
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A facilitative role for carbonic anhydrase activity in matrix vesicle mineralization

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Cited by 14 publications
(14 citation statements)
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“…Low pH can prevent HA formation by increasing solubility of formed mineral for which the optimal pH for crystal formation is in the range of 7.4-7.8 (Valhmu et al, 1990). However, extensive acidification during crystal formation is prevented by type II carbonic anhydrase (Stechschulte et al, 1992;Sauer et al, 1994).…”
Section: Factors Affecting Annexin Ion Channel Formationmentioning
confidence: 99%
“…Low pH can prevent HA formation by increasing solubility of formed mineral for which the optimal pH for crystal formation is in the range of 7.4-7.8 (Valhmu et al, 1990). However, extensive acidification during crystal formation is prevented by type II carbonic anhydrase (Stechschulte et al, 1992;Sauer et al, 1994).…”
Section: Factors Affecting Annexin Ion Channel Formationmentioning
confidence: 99%
“…The mineralization of cartilaginous tissue matrix is marked by the formation of hydroxyapatite [Ca 10 (PO 4 ) 6 (OH) 2 ] and deposition of calcium carbonate (CaCO 3 ) [15]. CAs II and III are present in matrix vesicles that initiate cartilage mineralization, indicating roles of CAs in cartilage calciWcation [16,17].…”
Section: Introductionmentioning
confidence: 99%
“…In recent years, 16 CA isoenzymes have been discovered in a variety of tissues, of which 13 are functional [18]. Only a few CAs have been studied in cartilage, mostly CAs I, II and III [19][20][21].…”
Section: Introductionmentioning
confidence: 99%
“…They are limited by a trilaminar unit membrane and contain a faintly granular matrix after staining. The molecular composition and the enzymatic activity of the MVs have been analyzed in recent biochemical and histochemical studies (Bonucci 1984;Kogaya and Furuhashi 1985;Takano et al 1986;Kitamura et al 1991;Hus et al 1993;Sauer et al 1994;Kirsch and Wuthier 1994). In the surrounding extravesicular matrix, acidic proteoglycans are believed to have a radial arrangement emerging from the outer membrane of the MVs (Wu et al 1991).…”
Section: Introductionmentioning
confidence: 99%