A factor analysis for complex systems containing nimesulide

Solid dispersions can be successfully prepared by simple fusion, hot melt extrusion, spray drying, freeze drying and supercritical fluid precipitation. Hot melt extrusion, spray drying and freeze drying are processes that can be applied for large scale production. The simple fusion method is not very suitable for large scale production, but is particularly suitable for screening formulations. The most recent method to produce sold dispersions is supercritical fluid precipitation. The process conditions of this method need extensive investigation, in particular in relationship with the selection of the type of carrier and/or solvent. Both processes and formulation aspects strongly affect the characteristics of solid dispersion products. Furthermore, application of crystalline solid dispersions is gaining increasing interest because they are thermodynamically more stable than amorphous solid dispersions.

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Improved dissolution behavior of lipophilic drugs by solid dispersions: the production process as starting point for formulation considerations

Srinarong¹,

Waard²,

Frijlink³

et al. 2011

Expert Opinion on Drug Delivery

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A factor analysis for complex systems containing nimesulide

Cited by 1 publication

References 23 publications

Improved dissolution behavior of lipophilic drugs by solid dispersions: the production process as starting point for formulation considerations

Improved dissolution behavior of lipophilic drugs by solid dispersions: the production process as starting point for formulation considerations

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