Passenger vehicles equipped with conventional drives, in which the internal combustion engine is the only source of energy, dominate on Polish and European roads. Despite the trend of electrification of means of road transport, conventional vehicles are still the most frequently purchased by customers. An alternative are vehicles with a hybrid drive system. They are characterized by lower fuel consumption and lower emission of harmful exhaust compounds compared to conventional vehicles. The aim of this paper is to examine the dependence between route parameters and fuel consumption and emissions of harmful exhaust components of vehicles with a conventional and hybrid drive system.