Nonorthogonal multiple access (NOMA) is one of the few promising techniques that can ensure the achievement of benefits foreseen in next-generation 5G wireless networks and beyond. By using superposition coding, NOMA allows multiple users to share the same time and frequency resources, thereby enhancing user connectivity, spectral efficiency, and a considerable increase in user throughput. Interference mitigation is an important consideration in NOMA and is considerably more influencing in multicellular environments. First, a brief description of the impairments that can arise in a NOMA cellular network along with responsible factors is provided. Second, different approaches adopted to minimize these impairments are discussed. Finally, a possible solution is proposed that consists of a coordinated approach between the individual cells in the NOMA domain to minimize interferences and improve user throughput. Adaptive fractional frequency reuse (FFR) is used to allocate distinct frequency resources to edge users of different cells to minimize intercell interference in NOMA. Simulation results prove that the proposed NOMA scheme plays an important role in minimizing impairment effects and enhancing the SINR and the throughput performance of edge users while ensuring fairness in its design.