A False Positive I-131 MIBG Due to Dilated Renal Pelvis: A Case Report

Integrated Imaging Using MRI and 123| Metaiodobenzylguanidine Scintigraphy to Improve Sensitivity and Specificity in the Diagnosis of Pediatric Neuroblastoma

“…However, the diagnostic confidence score was low in these cases (Table 2). Misinterpretation of a normal renal pelvis as a neuroblastoma lesion has been reported [23] and occurred in two of our patients. Bonnin et al [20] described the spectrum of false-positive MIBG findings due to a physiologic uptake in a normal adrenal gland, in the bowel, and in the musculature, as confirmed in three of our patients.…”

Value of combined XCT/SPECT technology for avoiding false positive planar 123I-MIBG scintigraphy

“…However, 123 I-MIBG findings are characterized by their lack of anatomic details. Based on this limitation, retention of 123 I-MIBG within the renal pelvis may be interpreted as an MIBG-avid tumour, leading to a false positive diagnosis of phaeochromocytoma (1,2,6,18,25,30).…”

A Pitfall of Metaiodobenzylguanidine Scan: Paraganglioma in Close Proximity to Adrenocortical Adenoma

“…False positive findings of MIBG scan are suggested to be rare. Previously, there have been less than 20 reports of false positive cases (Shapiro et al, 1985b;Kao et al, 1996;Bahar et al, 1988;Bathmann et al, 1994;Krubsack et al, 1988;Sone et al, 1996;Rainis et al, 2000;Horne et al, 1991;Cortes-Blanco et al, 2000). We report the case of concurrent presentation of adrenocortical adenoma and paraganglioma, which due to MIBG finding was suspected to be intra-adrenal pheochromocytoma.…”

“…Although false positive findings of MIBG scan have been considered rare, almost 20 false such cases have been reported, due to various reasons (Shapiro et al, 1985b;Kao et al, 1996;Bahar et al, 1988;Bathmann et al, 1994;Krubsack et al, 1988;Sone et al, 1996;Rainis et al, 2000;Horne et al, 1991;Cortes-Blanco et al, 2000;Jacobs et al, 1990;Hanson et al, 1991;Gallar et al, 1993;Fischer et al, 1984;Letizia et al, 1998;Ünal et al, 1995;Burt et al, 2002). Prolonged retention of isotope due to dilated renal pelvis or hydronephrosis was the reason in 4 cases Kao et al, 1996;Bahar et al, 1988;Bathmann et al, 1994) and abnormalities in the route excretion was also possibly the reason in the case of a renal failure (Gallar et al, 1993), a small ischemic kidney (Horne et al, 1991), a kidney with renal artery stenosis (Cortes-Blanco et al, 2000) and a focal pyelonephritis (Jacobs et al, 1990). Adrenal tumor other than pheochromocytoma (adrenocortical adenoma, adrenocortical carcinoma or adrenal metastasis of choriocarcinoma) was the reason in at least 7 cases Krubsack et al, 1988;Sone et al, 1996;Rainis et al, 2000;Houghton et al, 1990;Horne et al, 1991;Letizia et al, 1998).…”