A familiarity signal in human anterior medial temporal cortex?

Henson, Richard N.; Cansino, Selene; Herron, Jane; Robb, William G.K.; Rugg, Michael D.

doi:10.1002/hipo.10117

Cited by 261 publications

(190 citation statements)

References 23 publications

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“…The key postulate is that perirhinal cortex can produce a familiarity signal sufficient for normal recognition on the forced-choice test with highly similar foils, which is consistent with other evidence suggesting that perirhinal cortex supports familiarity (Brown & Xiang, 1998;Davachi et al, 2003;Henson et al, 2003;Ranganath et al, 2004). However, the present data would cast doubt on a perirhinal proposal if this region were subject to severe dysfunction in MCI; further evidence on this point from AD and MCI patients is required given that even subtle pathology could have significant Figure 5.…”

Section: Discussionsupporting

confidence: 85%

When memory does not fail: Familiarity-based recognition in mild cognitive impairment and Alzheimer's disease.

et al. 2006

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Recognition can be guided by familiarity, a restricted form of retrieval devoid of contextual recall, or by recollection, which occurs when retrieval is sufficient to support the full experience of remembering an episode. Recollection and familiarity were disentangled by testing recognition memory using silhouette object drawings, high target-foil resemblance, and both yes-no and forced-choice procedures. Theoretically, forced-choice recognition could be mediated by familiarity alone. Alzheimer's disease and its preclinical stage, mild cognitive impairment (MCI), were associated with memory impairments that were greater on the yes-no test. Remarkably, forced-choice recognition was unequivocally normal in patients with MCI compared with age-matched controls. Neuropathology in hippocampus and entorhinal cortex, known to be present in MCI, presumably disrupted recollection while leaving familiarity-based recognition intact.

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Section: Discussionsupporting

confidence: 85%

When memory does not fail: Familiarity-based recognition in mild cognitive impairment and Alzheimer's disease.

et al. 2006

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“…Parallel findings from functional imaging studies in humans have dissociated object processing in perirhinal cortex from spatial processing in the parahippocampal cortex (Pihlajamaki et al, 2004). Furthermore, whereas perirhinal cortex is activated in association with the memory strength of specific stimuli (Henson et al, 2003), the parahippocampal cortex is activated during recall of spatial and non-spatial context (Ranganath et al, 2003;Bar & Aminoff, 2003).…”

Section: Parahippocampal Cortex and Medial Entorhinal Areamentioning

confidence: 77%

“…Third, many cells have enhanced or suppressed responses to stimuli when they re-appear in a recognition test, indicating involvement in the recognition judgment. Similarly, in humans, among all areas within the medial temporal lobe, the perirhinal area selectively shows suppressed responses to familiar stimuli (Henson, Cansino, Herron, Robb, & Rugg, 2003). Complementary studies in animals with damage to the perirhinal cortex indicate that this area may be critical to memory for individual stimuli in the delayed non-matching to sample task in rats (Mumby & Pinel, 1994;Otto & Eichenbaum, 1992) and monkeys (Suzuki, Zola-Morgan, Squire, & Amaral, 1993).…”

Section: Perirhinal Cortex and Lateral Entorhinal Areamentioning

confidence: 98%

“…Complementary studies in animals with damage to the perirhinal cortex indicate that this area may be critical to memory for individual stimuli in the delayed non-matching to sample task in rats (Mumby & Pinel, 1994;Otto & Eichenbaum, 1992) and monkeys (Suzuki, Zola-Morgan, Squire, & Amaral, 1993). These and other data have led several investigators to the view that the perirhinal cortex is specialized for identifying the memory strength of individual stimuli (e.g., Brown & Aggleton, 2001;Henson et al, 2003;Aggleton, Kyd, & Bilkey, 2004). …”

Section: Perirhinal Cortex and Lateral Entorhinal Areamentioning

confidence: 99%

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Comparative Cognition, Hippocampal Function, and Recollection

Eichenbaum¹

2006

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“…Moreover, there is an ongoing discussion about the precise role of the anterior parahippocampal region in declarative memory (Schacter and Wagner, 1999). At least, it has been shown that this region plays a critical role in the formation of new declarative memories with an activity increase (Fernández et al, 1999(Fernández et al, , 2002Grasby et al, 1993;Otten et al, 2001;Petersson et al, 1999a;Strange et al, 2002;Tulving et al, 1999;Weis et al, 2004) and in recognition based on familiarity with an activity decrease (Brown and Aggleton, 2001;Henson et al, 2003). Thus, one might speculate that the reduced recognitionrelated activity in the anterior parahippocampal gyrus in young subjects (Fig.…”

Section: Discussionmentioning

confidence: 99%

Age differences in neural correlates of route encoding and route recognition

et al. 2004

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Spatial memory deficits are core features of aging-related changes in cognitive abilities. The neural correlates of these deficits are largely unknown. In the present study, we investigated the neural underpinnings of age-related differences in spatial memory by functional MRI using a navigational memory task with route encoding and route recognition conditions. We investigated 20 healthy young (18 -29 years old) and 20 healthy old adults (53 -78 years old) in a random effects analysis. Old subjects showed slightly poorer performance than young subjects. Compared to the control condition, route encoding and route recognition showed activation of the dorsal and ventral visual processing streams and the frontal eye fields in both groups of subjects. Compared to old adults, young subjects showed during route encoding stronger activations in the dorsal and the ventral visual processing stream (supramarginal gyrus and posterior fusiform/parahippocampal areas). In addition, young subjects showed weaker anterior parahippocampal activity during route recognition compared to the old group. In contrast, old compared to young subjects showed less suppressed activity in the left perisylvian region and the anterior cingulate cortex during route encoding. Our findings suggest that agerelated navigational memory deficits might be caused by less effective route encoding based on reduced posterior fusiform/parahippocampal and parietal functionality combined with diminished inhibition of perisylvian and anterior cingulate cortices correlated with less effective suppression of task-irrelevant information. In contrast, age differences in neural correlates of route recognition seem to be rather subtle. Old subjects might show a diminished familiarity signal during route recognition in the anterior parahippocampal region. D

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A familiarity signal in human anterior medial temporal cortex?

Cited by 261 publications

References 23 publications

When memory does not fail: Familiarity-based recognition in mild cognitive impairment and Alzheimer's disease.

When memory does not fail: Familiarity-based recognition in mild cognitive impairment and Alzheimer's disease.

Comparative Cognition, Hippocampal Function, and Recollection

Age differences in neural correlates of route encoding and route recognition

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