A family cluster of diagnosed coronavirus disease 2019 (COVID‐19) kidney transplant recipient in Thailand

Abstract

Introduction Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) causes an ongoing outbreak of respiratory illness called coronavirus disease 2019 (COVID‐19). The clinical course could be ranging from mild to severe illness especially the individuals with an immunocompromised condition such as solid organ transplant recipients. Method We described a family cluster of COVID‐19 patients who were admitted during 3rd April 2020 to 30th April 2020. COVID‐19 was confirmed by a presence of SARS‐CoV‐2 ribonucleic acid in the respiratory specimens detected by a qualitative, real‐time reverse transcription‐polymerase chain reaction. The study focused on the clinical course and management of our cases. Results A family cluster of four laboratory‐confirmed COVID‐19 patients, one of those carried an underlying kidney transplant (KT) receiving immunosuppressants. Clinical presentation and severity of our case series are variable depending on each individual immune status. By far, a KT recipient seems to develop more severity despite antiviral therapy, cessation of immunosuppressant, and aggressive intensive care support. Conclusion Our case series plausibly affirmed a person‐to‐person transmission and potentially severe disease in the transplant population. Clinicians who are encountering with transplant recipients should be aware of possible transmission among family members.

The Management of Immunosuppression in Kidney Transplant Recipients with COVID-19 Disease: An Update and Systematic Review of the Literature

“…Given the paucity of patients identified within the selection criteria in each selected article, the results are reported as a narrative review. Data extracted from each study [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 …”

SARS-CoV-2-specific humoral and cell-mediated immune responses after immunization with inactivated COVID-19 vaccine in kidney transplant recipients (CVIM 1 study)

“… 1 Solid organ transplant (SOT) recipients are among those who are potentially compromised for this particular infection, resulting in significant morbidity and substantial mortality in this demographic. 2 , 3 , 4 , 5 Vaccination against SARS‐CoV‐2 is recommended to ameliorate this potentially serious infection and its unfavorable consequences. Various COVID‐19 vaccines have been developed across a range of platforms and have been deployed among immunocompetent individuals.…”

Renal involvement in COVID-19: focus on kidney transplant sector

“…All family members recovered [ 124 ]. Sakulkonkij et al described a family cluster of four COVID‐19 patients occurred in Thailand, of whom one was a kidney transplant recipient under immunosuppressive treatment [ 144 ]. The clinical presentation and the severity of COVID-19 were different in these four patients, depending on the immune status of subjects.…”

“…The clinical presentation and the severity of COVID-19 were different in these four patients, depending on the immune status of subjects. The 38-year-old son of the female index case who underwent living-related kidney transplantation in 2014 showed allograft disfunction and a severe course of the illness with a severe pneumonia and Clostrioides difficile colitis requiring intensive treatment [ 144 ]. All patients recovered and became PCR negative for SARS-2CoV-2, even if repeated testing showed a prolonged positivity in the lower respiratory tract of the kidney transplant recipient.…”