A family of linear phenolic polymers with controlled hydrophobicity, adsorption and antioxidant properties

Hlushko, Raman; Hlushko, Hanna; Sukhishvili, Svetlana A.

doi:10.1039/c7py01973d

Cited by 38 publications

(44 citation statements)

References 55 publications

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“…[56] In another recent example of synthesized phenolic monomers, linear polymeric antioxidants were prepared with complex catechol-and gallol-like functional groups, which allowed for control over a variety of material properties such as hydrophobicity. [57] Though an array of synthetic monomers and polymers have been synthesized, with near endless possibilities for future structures, other factors beyond simply the addition of phenolic moieties need to be considered. Specifically, numerous fundamental studies have begun to explore the structure-function relationships between the components of synthetic phenolic polymers.…”

Section: Reviewmentioning

confidence: 99%

Phenolic Building Blocks for the Assembly of Functional Materials

et al. 2018

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Phenolic materials have long been known for their use in inks, wood coatings, and leather tanning. However, recently there has been a renewed interest in engineering advanced materials from phenolic building blocks. The intrinsic properties of phenolic compounds, such as metal chelation, hydrogen bonding, pH responsiveness, redox potentials, radical scavenging, polymerization, and light absorbance, have made them a distinct class of structural motifs for the synthesis of functional materials. Materials prepared from phenolic compounds often retain many of these useful properties with synergistic effects in applications ranging from catalysis to biomedicine. The present review provides an overview of the diverse functional materials that can be prepared from phenolic building blocks, bridging the various fields currently studying and using phenolic compounds. Natural and synthetic phenolic compounds are first discussed, followed by the assembly of functional materials. The engineered phenolic materials are grouped under three broad categories: thin films (e.g., metal-phenolic networks and polydopamine); particles (e.g., metal-organic frameworks and superstructures); and bulk materials (e.g., gels). Applications of phenolic-based materials are then presented, focusing mainly on mechanical (e.g., adhesives), biological (e.g., drug delivery), and environmental and energy (e.g., separation and catalysis) applications. Several examples of their emerging applications are also included. Finally, potential routes for the continued integration of disparate fields using phenolic building blocks and fundamental questions still requiring investigation are highlighted, and an outlook of the field is provided.

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Section: Reviewmentioning

confidence: 99%

Phenolic Building Blocks for the Assembly of Functional Materials

et al. 2018

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“…These were synthesized by reversible addition‐fragmentation chain transfer (RAFT) polymerization of poly(methacrylamide) with polyphenolic compounds. [ 228 ] However, the efficiency of the materials described above against NDs has not yet been evaluated.…”

Section: Nanocarrier‐based Delivery Of Antioxidantsmentioning

confidence: 99%

Redox‐Responsive Nanobiomaterials‐Based Therapeutics for Neurodegenerative Diseases

Eleftheriadou

Kesidou

Moura

et al. 2020

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dementia, which result from chronic and progressive loss of neuronal function. In view of an ageing population, disorders of the brain are likely to establish the principal economic challenge in the future of healthcare. [1] The total cost of dementia to society in the UK alone is £26.3 billion, and this is expected to double over the next 30 years given that prevalence is projected to rise by 40% in the coming decade alone. [2] Among NDs, significant attention has been paid to Alzheimer's disease (AD) and Parkinson's disease (PD) given their severe complications and economic burdens. AD, which accounts for the vast majority of age-related dementia, is a progressive disorder that is characterized by gradual neuronal loss and accumulation of proteins, namely extracellular amyloid-β plaques and intracellular tau tangles. [3] PD is a progressive ND resulting from the loss of specific dopaminergic (DA) neurons in the substantia nigra pars compacta and reduced DA levels in the nigrostriatal DA pathway in the brain. [4,5] Despite significant progress in the management of NDs over the recent years, the early diagnostic and treatment options remain limited. Patients currently suffering from NDs have no available disease-modifying treatments. Instead, patients are offered a therapeutic plan focused on the management of their ND symptoms, whilst concurrently attempting to reduce the adverse effects associated with the medications used. The systemic delivery of drugs to the central nervous system (CNS) is complex due to their poor delivery to the brain, extensive firstpass metabolism which reduces their half-life, and the sideeffects resulting from the drug acting on non-target peripheral tissues. [6] The mainstay of current treatments for NDs is typically through oral administration. For PD medications include L-dopa, carbidopa (peripheral inhibitor of L-dopa into DOPA), dopaminergic agonists, Entacapone (Catechol-O-methyl transferase inhibitor), monoamine oxidase-B inhibitors, amongst others. Other routes of drug administration exist such as subcutaneous injection of dopaminergic agonists. Interestingly, deep brain stimulation has also been offered to those patients resistant to medical therapy but again associated with significant adverse effects. L-Dopa, which is considered the most effective treatment in the short-term for PD, [7] is related to longterm wearing-off phenomena, dyskinesias, and neuropsychiatric disorders. [8] Redox regulation has recently been proposed as a critical intracellular mechanism affecting cell survival, proliferation, and differentiation. Redox homeostasis has also been implicated in a variety of degenerative neurological disorders such as Parkinson's and Alzheimer's disease. In fact, it is hypothesized that markers of oxidative stress precede pathologic lesions in Alzheimer's disease and other neurodegenerative diseases. Several therapeutic approaches have been suggested so far to improve the endogenous defense against oxidative stress and its harmful effects. Among such approaches, the use o...

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“…Furthermore, 4-bromo catechols (Figure 2d) and pyrogallols (Figure 2j) have been tested for use in polymeric antioxidants [92,93]. In general, extensive studies on pyrogallolic species (also called tannins) have been developed during recent years for countless applications.…”

Section: Dopa Analogues: Other Polyphenolsmentioning

confidence: 99%

Bioinspired Metal–Polyphenol Materials: Self-Healing and Beyond

2019

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The blue mussel incorporates the polyphenolic amino acid l-3,4-dihydroxyphenylalanine (DOPA) to achieve self-healing, pH-responsiveness, and impressive underwater adhesion in the byssus threads that ensure the survival of the animal. This is achieved by a pH-dependent and versatile reaction chemistry of polyphenols, including both physical interactions as well as reversible and irreversible chemical bonding. With a short introduction to the biological background, we here review the latest advances in the development of smart materials based on the metal-chelating capabilities of polyphenols. We focus on new ways of utilizing the polyphenolic properties, including studies on the modifications of the nearby chemical environment (on and near the polyphenolic moiety) and on the incorporation of polyphenols into untraditional materials.

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A family of linear phenolic polymers with controlled hydrophobicity, adsorption and antioxidant properties

Abstract: The synthesis of a series of antioxidant polymers with varied capability to scavenge radicals and alter the wettability of surfaces is reported.

Cited by 38 publications

References 55 publications

Phenolic Building Blocks for the Assembly of Functional Materials

Phenolic Building Blocks for the Assembly of Functional Materials

Redox‐Responsive Nanobiomaterials‐Based Therapeutics for Neurodegenerative Diseases

Bioinspired Metal–Polyphenol Materials: Self-Healing and Beyond

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