A family of molecules related to collapsin in the embryonic chick nervous system

Luo, Yuling; Shepherd, Iain T.; Li, Jie; Renzi, Michael; Chang, Sun Ju; Raper, Jonathan A.

doi:10.1016/0896-6273(95)90261-9

Cited by 211 publications

(123 citation statements)

References 43 publications

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“…We sequenced approximately 60 clones and analyzed the sequence by nucleotide and translated blast analyses using the programs provided by National Center for Biotechnology Information (NCBI). Several clones were confirmed as identical to the previously reported chick Sema3D gene (Luo et al, 1995;Chilton and Guthrie, 2003;Watanabe et al, 2004;Jin et al, 2006). Another clone was found to be identical to the newly annotated Sema7A gene from the chick genomic sequence (accession number: XM_413687), except a stretch of 44 nucleotides (Fig.…”

Section: Sema7a Partial Cdna Clonesupporting

confidence: 58%

Sema3D and Sema7A have distinct expression patterns in chick embryonic development

Bao

Jin

2006

Developmental Dynamics

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By RT-PCR, we isolated a partial cDNA clone for the chick Semaphorin7A (Sema7A) gene. We further analyzed its expression patterns and compared them with those of the Sema3D gene, in chick embryonic development. Sema3D and Sema7A appeared to be expressed in distinct cell populations. In mesodermderived structures, Sema7A expression was detected in the newly formed somites, whereas Sema3D expression was found in the notochord. In ectoderm-derived tissues, Sema3D is expressed broadly in the surface ectoderm, lens and nasal placodes. Sema3D is also expressed in the developing nervous system including diencephalon, dorsal neural tube, optical and otic vesicles. In the limb bud, Sema3D expression was found throughout the ectoderm excluding the apical ectoderm ridge (AER), where Sema7A is concentrated. Although both genes appeared to be expressed in the migrating neural crest cells, Sema3D expression is limited to neural crest cells migrating out of the midbrain/hindbrain regions, while Sema7A expression is widespread in both cranial and trunk neural crest cells. Developmental Dynamics 235: 2282-2289, 2006.

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Section: Sema7a Partial Cdna Clonesupporting

confidence: 58%

Sema3D and Sema7A have distinct expression patterns in chick embryonic development

Bao

Jin

2006

Developmental Dynamics

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“…6,7 In less than 10 years, more than 30 semaphorins have been cloned in mammals and some orthologs have been found in virtually all animal phyla and in certain DNA viruses. 8 Eight semaphorin subclasses were distinguished based on sequence similarity and distinctive structural features.…”

Section: Semaphorins and Their Receptorsmentioning

confidence: 99%

The brain within the tumor: new roles for axon guidance molecules in cancers

2005

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Slits, semaphorins and netrins are three families of proteins that can attract or repel growing axons and migrating neurons in the developing nervous system of vertebrates and invertebrates. Recent studies have shown that they are widely expressed outside the nervous system and that they may play important roles in cancers. Several of the genes encoding these proteins are localized on chromosomal region associated with frequent loss-of-heterozygosity in tumors and cancer cell lines and there is also significant hypermethylation of their promoter suggesting that they may act as tumor suppressors. In addition, proteins in all these families and their receptors appear to control the vascularization of the tumors. Last, many axon guidance molecules also regulate cell migration and apoptosis in normal and tumorigenic tissues. Overall, this suggests that molecules that could mimick or block the activity of axon guidance molecules may be used as therapeutic agents for the treatment of malignancy.

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“…The posthybridisation RNaseA treatment was omitted, and alkaline phosphatase-conjugated F ab fragments were preabsorbed in 10% heat-inactivated sheep serum, instead of embryo powder. The NPN1, Sema3A, Sema3C, Sema3D, Sema3E, and NPN2 probes have been described previously (Herzog et al, 2001;Luo et al, 1995). Control hybridisations were carried out by using the sense strand, and in no case was a signal observed.…”

Section: Mrna In Situ Hybridisationmentioning

confidence: 99%

Cranial expression of class 3 secreted semaphorins and their neuropilin receptors

Chilton

Guthrie

2003

Developmental Dynamics

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The semaphorin family of chemorepellents and their receptors the neuropilins are implicated in a variety of cellular processes, including axon guidance and cell migration. Semaphorins may bind more than one neuropilin or a heterodimer of both, thus a detailed knowledge of their expression patterns may reveal possible cases of redundancy or mutual antagonism. To assess their involvement in cranial development, we cloned fragments of the chick orthologues of Sema3B and Sema3F. We then carried out mRNA in situ hybridisation of all six class 3 semaphorins and both neuropilins in the embryonic chick head. We present evidence for spatiotemporal regulation of these molecules in the brainstem and developing head, including the eye, ear, and branchial arches. These expression patterns provide a basis for functional analysis of semaphorins and neuropilins in the development of axon projections and the morphogenesis of cranial structures. Developmental Dynamics 228:726 -733, 2003.

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A family of molecules related to collapsin in the embryonic chick nervous system

Cited by 211 publications

References 43 publications

Sema3D and Sema7A have distinct expression patterns in chick embryonic development

Sema3D and Sema7A have distinct expression patterns in chick embryonic development

The brain within the tumor: new roles for axon guidance molecules in cancers

Cranial expression of class 3 secreted semaphorins and their neuropilin receptors

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