A family of pernicious anemia associated with Osler's disease.

Koizumi, Koichi; Ikarashi, Yoshiharu; Nakamura, Hiroki; Saito, Soichi; Sato, Shinji; Ando, Haruo; Sasaki, Hideo

doi:10.2169/naika.77.1731

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“…[5][6][7][8][9][10][11] However, its association with thyroid disease is not reported yet. To our knowledge, this is the first case in which Hashimoto thyroiditis was associated with HHT.…”

Section: Discussionmentioning

confidence: 99%

“…1 Hereditary hemorrhagic telangiectasia can be related to other diseases of autoimmune etiology such as scleroderma, pernicious anemia, pulmonary sarcoidosis, polyarthritis, disseminated lupus erythematosus, and the antiphospholipid antibody syndrome. [5][6][7][8][9][10][11] We describe a patient with HHT who also has autoimmune (Hashimoto) thyroiditis. This organspecific autoimmune disease accompanies many other autoimmune diseases.…”

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confidence: 99%

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Hashimoto Thyroiditis in a Patient With Hereditary Hemorrhagic Telangiectasia

Sabuncu

Tabur

Yasar

et al. 2006

The Endocrinologist

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Hereditary hemorrhagic telangiectasia (HHT) is an autosomal-dominant disorder with incomplete penetrance characterized by vascular anomalies that can develop in many organs. The diagnosis is based on 4 clinical criteria: family history, epistaxis, mucocutaneous telangiectasias, and arteriovenous malformations. Hereditary hemorrhagic telangiectasia is associated with many autoimmune diseases. An association with thyroid disease has not been reported. In a patient with HHT, we first identified chronic autoimmune (Hashimoto) thyroiditis, which is an organ-specific autoimmune disease and accompanies many other autoimmune diseases. The diagnosis of HTT was made by the findings of a positive family history, multiple telangiectatic lesions, and recurrent epistaxis. Nevertheless, we identified Hashimoto thyroiditis in this patient by the abnormalities of thyroid hormones, serum autoantibodies, radiographic and physical findings. Clinical improvement was seen by using blood transfusions, oral ferrum, and levothyroxine sodium therapy. In conclusion, in the existence of recurrent epistaxis and telangiectasias or a family history of these symptoms, HHT should be taken into consideration, and also Hashimoto thyroiditis as well as other autoimmune diseases should also be screened in patients with HHT.

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“…[5][6][7][8][9][10][11] However, its association with thyroid disease is not reported yet. To our knowledge, this is the first case in which Hashimoto thyroiditis was associated with HHT.…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%