A Family Study of Consanguinity in Children with Intellectual Disabilities in Barwani, India

Lakhan, Ram; Bipeta, Rajshekhar; Yerramilli, Srinivasa Srr; Nahar, Vinayak K.

doi:10.4103/jnrp.jnrp_104_17

Cited by 11 publications

(9 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The causes of ID are quite heterogeneous, as they may be due to factors of genetic, environmental or multifactorial origin [ 13 , 14 ], however 25 to 60% are attributed to genetic causes [ 15 – 17 ]. The evaluation of the ID traditionally is done through psychometric tests of intelligence, known as an Intelligence Quotient (IQ) test, that nowadays include evaluation of adaptive functioning or life skills [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Etiology of intellectual disability in individuals from special education schools in the south of Brazil

et al. 2020

View full text Add to dashboard Cite

Background Intellectual Disability (ID) is characterized by significant limitations that affect intellectual functioning, adaptive behavior, and practical skills which directly interfere with interpersonal relationships and the environment. In Western countries, individuals with ID are overrepresented in the health system, often due to associated comorbidities, and its life-time cost places ID as one of the most expensive conditions of all diagnoses in the International Classification of Diseases. Most of the people affected (75%) live in low-income countries, suffer from malnutrition, lack health care, and do not have access to adequate treatment. The aim of this study was to obtain an estimate of the diagnostic status as well as the prevalence of familial ID among individuals with serious (moderate or severe) ID in a region of the State of Santa Catarina, investigating attendees of special education schools of the Florianópolis Macroregion. Methods This was a cross-sectional study conducted between August 2011 and August 2014, through a semi-structured screening questionnaire for the collection of relevant developmental, clinical, familial and educational data, applied in an interview to guardians of students of special education schools of the macroregion of Florianópolis. Results The participant special schools enrolled close to 1700 students during the study period and the questionnaire was applied to 849 (50.5%). The male to female ratio of the participants was 1.39:1. Clear etiologic explanations were relatively scarce (24%); most diagnoses referring only to the type and the degree of impairment and for the majority (61.4%) the cause was unknown. About half were sporadic cases within their families (considering three generations). For 44.2% at least one other case of an ID-related condition in the extended family was mentioned, with 293 (34.5%) representing potential familial cases. Conclusion Here we describe the epidemiological profile, the available diagnostics, etiology, family history and possible parental consanguinity of participants with ID of special education schools in the South of Brazil. The main results show the need for etiological diagnosis and uncover the relevance of potential hereditary cases in a population where consanguineous unions have a relatively low frequency (0,6%) and highlight the need for public health actions.

show abstract

Section: Introductionmentioning

confidence: 99%

Etiology of intellectual disability in individuals from special education schools in the south of Brazil

et al. 2020

View full text Add to dashboard Cite

show abstract

“… Consanguinity is a well-known risk factor for genetic disorder. The consanguineous marriages may able playing a crucial role in transferring ID (intellectual disabilities) in children from their ID relatives and primarily, consanguinity is a social factor (Lakhan R et al 2017). Out of 5 total cases, in 3 cases consanguineous marriage was practiced.…”

Section: Resultsmentioning

confidence: 99%

Challenges of Parents with Two Intellectually Disabled Children

Francina¹,

Tintu

Ivan

2018

ajs

View full text Add to dashboard Cite

This study was conducted to assess the psycho-social problems faced by parents with more than one intellectually disabled child in Mangalapuram Panchayath of Trivandrum District, Kerala. The psychosocial elements considered for this qualitative study includes emotional adaptability of parents, the role of support systems and the precautions taken by the family after the birth of the first child. Data were collected from 5 cases selected from the 15 cases identified in Mangalapuram panchayath. The cases were purposively selected from parents having minimum two disabled children. Data were collected using a semi-structured interview guide as a tool. The difficulty faced by the families with two disabled children reveals multiple levels of stress when compared to families with typically developing children. Such families face problems ranging from financial aspects to the physical, psychological and social aspects, which in turn affect their quality of life.

show abstract

“…29 To avoid the spread of these types of disease, couples who desire such a relationship (between relatives), and yet present some type of mental disorder, require genetic counseling. 30…”

Section: Discussionmentioning

confidence: 99%

Analyzing Inbreeding and Estimating Its Related Deficiencies in Northeastern Brazil

et al. 2021

View full text Add to dashboard Cite

This cross-sectional study aimed to observe number of marriages between relatives in São Francisco Valley municipalities and correlations between degrees of kinship and susceptibility to genetic diseases. Three hundred and nine (309) consanguineous couples were interviewed in five municipalities. The data were analyzed using SPSS (version 22), Chi-square testing, and the generalized estimating equation (GEE). In Pariconha-AL for first cousins, the results revealed significantly higher numbers of disabled children than for third cousins (p < 0.05). Of these, the prevalence for physical disability was significant (χ2 = 19.203, df = 4, p = 0.001). In the cities of Glória-BA (χ2 = 11.652, df = 3, p = 0.020) and OlhoD'água do Casado-AL (χ2 = 8.123, df = 4, p = 0.044), physical disabilities were also significantly higher in children from unions of first-degree cousins than for other degrees of kinship. Visual impairment was more significant in first-degree cousins in Glória-BA (χ2 = 14.206, df = 3 p = 0.007); yet among third-degree cousins, visual impairment in the municipality of Santa Brígida-BA was more prevalent (χ2 = 6.416, df = 2 p = 0.040). Inbreeding, as revealed in the evaluated cities, reinforces the hypothesis for developing genetic diseases.

show abstract

A Family Study of Consanguinity in Children with Intellectual Disabilities in Barwani, India

Cited by 11 publications

References 20 publications

Etiology of intellectual disability in individuals from special education schools in the south of Brazil

Etiology of intellectual disability in individuals from special education schools in the south of Brazil

Challenges of Parents with Two Intellectually Disabled Children

Analyzing Inbreeding and Estimating Its Related Deficiencies in Northeastern Brazil

Contact Info

Product

Resources

About