A Family Study of Pernicious Anaemia

The Augmented Histamine Test with Special Reference to Achlorhydria

“…Twelve subjects were relatives of patients with pernicious anaemia who had been found in a previous survey to have achlorhydria either to the diagnex test or the ordinary histamine test (Callender and Denborough, 1957).…”

‘Latent’ Pernicious Anaemia in Delhi (India)

“…Callender and Denborough [4] and McIntyre et al [16] found in creased frequency of achlorhydria, low levels of serum vitamin B12 and decreased urinary excretion of pepsinogen amongst close relatives of pa tients with pernicious anaemia, and concluded that these were probably features of 'latent' pernicious anaemia. Subsequently, Wangel et al [20] observed an association between gastric parietal cell antibody, low serum vitamin Bl2 and pepsinogen levels amongst the first degree rela tives of pernicious anaemia patients and recognized a higher frequency of prevalence of the latent form of this disease in these groups of sub jects.…”

The Absorption of Vitamin B₁₂ in the Elderly

“…secretion, as it has been well-established that there is independent secretion of acid, pepsin and I.F. by the stomach {Callender and Denborough, 1957;Poliner and Spiro, 1958).…”