A Fasciclin 2 functional switch controls organ size in <i>Drosophila</i>

Velasquez, Emma; Gomez-Sanchez, Jose A.; Donier, Emmanuelle; Grijota-Martínez, Carmen; Cabedo, Hugo; García‐Alonso, Luis

doi:10.1101/356196

Cited by 1 publication

(3 citation statements)

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“…It never expresses in the undifferentiated cells anterior to the morphogenetic furrow but mainly localizes at the furrow, decreasing further to the posterior of the disc ( figure 11 a ). Fas2 promotes EGFR signalling during the growth of the imaginal disc [ 69 ] that causes cell-specific expression of Fas2, suggesting a self-regulatory feedback loop between Fas2 and EGFR during eye disc development. Hence, the loss of fas2 is reported to reduce the growth and proliferation of eye disc cells [ 69 ].…”

Section: Resultsmentioning

confidence: 99%

“…Fas2 promotes EGFR signalling during the growth of the imaginal disc [ 69 ] that causes cell-specific expression of Fas2, suggesting a self-regulatory feedback loop between Fas2 and EGFR during eye disc development. Hence, the loss of fas2 is reported to reduce the growth and proliferation of eye disc cells [ 69 ]. Aop repress EGFR and is degraded upon the Fas2 downregulation [ 20 ].…”

Section: Resultsmentioning

confidence: 99%

“…Hence, the loss of fas2 is reported to reduce the growth and proliferation of eye disc cells [69]. Aop repress EGFR and is degraded upon the Fas2 downregulation [20].…”

Section: Rpd3 Regulates the Expression Of Different Genes In Neural D...mentioning

confidence: 99%

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Histone deacetylase (Rpd3) regulates Drosophila early brain development via regulation of Tailless

Das

Bhadra

2020

Open Biol.

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Tailless is a committed transcriptional repressor and principal regulator of the brain and eye development in Drosophila . Rpd3, the histone deacetylase, is an established repressor that interacts with co-repressors like Sin3a, Prospero, Brakeless and Atrophin. This study aims at deciphering the role of Rpd3 in embryonic segmentation and larval brain development in Drosophila . It delineates the mechanism of Tailless regulation by Rpd3 , along with its interacting partners. There was a significant reduction in Tailless in Rpd3 heteroallelic mutant embryos, substantiating that Rpd3 is indispensable for the normal Tailless expression. The expression of the primary readout, Tailless was correlative to the expression of the neural cell adhesion molecule homologue, Fascilin2 (Fas2). Rpd3 also aids in the proper development of the mushroom body. Both Tailless and Fas2 expression are reported to be antagonistic to the epidermal growth factor receptor (EGFR) expression. The decrease in Tailless and Fas2 expression highlights that EGFR is upregulated in the larval mutants, hindering brain development. This study outlines the axis comprising Rpd3, dEGFR, Tailless and Fas2, which interact to fine-tune the early segmentation and larval brain development. Therefore, Rpd3 along with Tailless has immense significance in early embryogenesis and development of the larval brain.

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Section: Resultsmentioning

confidence: 99%