Using historical cases' solutions to obtain feasible solution for new problem is fundamentally to successfully applying case-based reason technique in parametric mechanical design. As a well-known intelligent algorithm, the formulation of support vector regression has been taken for case-based reason adaptation, but the standard support vector regression can only be used as a univariate adaptation method because of its single-output structure, which would result in the ignorance of the possible interrelations among solution outputs. To handle the complicated case adaptation task with large number of problem inputs and solution outputs more efficiently, this study investigates the possibility of multivariable case-based reason adaptation with multiple output by applying multiple-output support vector regression. Furthermore, inspired by the fact that training sample which contains two closer cases can provide more useful information than others, this study adds the similarity-related weight into multiple-output support vector regression and gives high weights to the information provided by such useful training sample during multi-dimensional regression estimation. The superiority of proposed multiple-output support vector regression with similarity-related weight is validated by the actual design example and quantitative comparisons with other adaptation methods. The comparative results indicate that multiple-output support vector regression with similarity-related weight achieves the best performance for largequantity case-based reason adaptation because of its higher accuracy and relatively lower cost.