A fast and simple electrochemical impedance spectroscopy measurement technique and its application in portable, low-cost instrument for impedimetric biosensing

Huang, Xinjian; Chen, Huilian; Deng, Haiqiang; Wang, Lishi; Liao, Shijun; Tang, Aimin

doi:10.1016/j.jelechem.2011.04.011

Cited by 20 publications

(21 citation statements)

References 20 publications

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“…These methods using Fourier transformation are called FFT impedance or FT-EIS. It was reported that white noise [11,12], pseudo-random noise (pseudo-white noise) [12][13][14][15][16][17], pseudo-random signals [18], multi-sine waves (superimposed sine waves) [19,20], step signals [10,12,[21][22][23][24][25], and square pulses [26,27] can be applied to FFT impedance. An on-line FFT impedance measurement system using pseudo-white noise as the input signal was developed by one of our authors [14,15], and its application to in situ EIS was reported [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Application of Electrochemical Impedance Spectroscopy to Ferri/Ferrocyanide Redox Couple and Lithium Ion Battery Systems Using a Square Wave as Signal Input

Yokoshima

Mukoyama

Nakazawa

et al. 2015

Electrochimica Acta

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Section: Introductionmentioning

confidence: 99%

Application of Electrochemical Impedance Spectroscopy to Ferri/Ferrocyanide Redox Couple and Lithium Ion Battery Systems Using a Square Wave as Signal Input

Yokoshima

Mukoyama

Nakazawa

et al. 2015

Electrochimica Acta

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“…Since the full impedance spectrum is a time-consuming technique, Huang et al [50] employed a potential stepbased time domain impedance measurement. All the operational amplifiers in the potentiostat have a bandwidth greater than 1 MHz.…”

Section: Journal Of Sensorsmentioning

confidence: 99%

“…In all cases, the potentiometric response is determined by ion conduction processes and ion exchange reactions at Figure 17: Impedance spectra obtained by the STP method with varied sampling rates and the FRA method (red line). Reprinted from [50]. From an analysis of the works addressing the design of potentiometric potentiostats in the recent literature, the main concerns are the input impedance and input bias current.…”

Section: Potentiometric Protein Detectionmentioning

confidence: 99%

“…Another critical issue to take into account in designing a potentiostat is the frequency of the applied stimulus. Among the AC stimulus voltages, [50,51,55,64] employed the largest range of frequency from 0.1 Hz to 100 kHz, in order to ensure a proper impedimetric configuration. In order to design a highly accurate impedimetric potentiostat, key design considerations are the linearity of the output voltage and the stability of the system in achieving the desired frequency [40].…”

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confidence: 99%

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Potentiostats for Protein Biosensing: Design Considerations and Analysis on Measurement Characteristics

et al. 2019

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The demand for the development of swift, simple, and ultrasensitive biosensors has been increasing after the introduction of innovative approaches such as bioelectronics, nanotechnology, and electrochemistry. The possibility to correlate changes in electrical parameters with the concentration of protein biomarkers in biological samples is appealing to improve sensitivity, reliability, and repeatability of the biochemical assays currently available for protein investigation. Potentiostats are the required instruments to ensure the proper cell conditioning and signal processing in accurate electrochemical biosensing applications. In this light, this review is aimed at analyzing design considerations, electrical specifications, and measurement characteristics of potentiostats, specifically customized for protein detection. This review demonstrates how a proper potentiostat for protein quantification should be able to supply voltages in a range between few mV to few V, with high resolution in terms of readable current (in the order of 100 pA). To ensure a reliable quantification of clinically relevant protein concentrations (>1 ng/mL), the accuracy of the measurement (<1%) is significant and it can be ensured with proper digital-to-analog (10-16 bits) and analog-to-digital (10-24 bits) converters. Furthermore, the miniaturisation of electrochemical systems represents a key step toward portable, real-time, and fast point-of-care applications. This review is meant to serve as a guide for the design of customized potentiostats capable of a more proper and enhanced conditioning of electrochemical biosensors for protein detection.

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“…A small low-cost impedance measurement board using a microprocessor and several operational amplifiers for portable biosensing applications is presented in [7], where a voltage step is applied to the device under test (DUT) and the current is measured and sampled using analog-to-digital conversion (ADC). A DSP-based embedded frequency response analyzer for fuel cell monitoring and characterization is presented in [8], while a low-cost impedance spectroscopy system for fuel cell characterization is described in [9].…”

Section: Introductionmentioning

confidence: 99%

Estimation of membrane hydration status for standby proton exchange membrane fuel cell systems by impedance measurement: First impedance measurement circuit

Bidoggia

Rugholt

Busk

et al. 2014

2014 Ninth International Conference on Ecological Vehicles and Renewable Energies (EVER)

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Fuel cells are getting growing interest in both backup systems and electric vehicles. Although these systems are characterized by long periods of inactivity, they must be able to start at any instant in the shortest time. However, the membrane of which PEMFCs are made tends to dry out when not in use. This increases the time required to start the system and could lead to the destruction of the fuel cell. In this article an impedance measurement circuit is presented, which is part of a humidity status estimator for monitoring the humidity status of a fuel cell stack during standby. The impedance measurement circuit has been connected to a fuel cell stack and the operation of estimating the relative humidity has been demonstrated.

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A fast and simple electrochemical impedance spectroscopy measurement technique and its application in portable, low-cost instrument for impedimetric biosensing

Cited by 20 publications

References 20 publications

Application of Electrochemical Impedance Spectroscopy to Ferri/Ferrocyanide Redox Couple and Lithium Ion Battery Systems Using a Square Wave as Signal Input

Application of Electrochemical Impedance Spectroscopy to Ferri/Ferrocyanide Redox Couple and Lithium Ion Battery Systems Using a Square Wave as Signal Input

Potentiostats for Protein Biosensing: Design Considerations and Analysis on Measurement Characteristics

Estimation of membrane hydration status for standby proton exchange membrane fuel cell systems by impedance measurement: First impedance measurement circuit

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