A fast field-cycling device for high-resolution NMR: Design and application to spin relaxation and hyperpolarization experiments

SABRE Hyperpolarization of Bipyridine Stabilized Ir-Complex at High, Low and Ultralow Magnetic Fields

“…Low field experiments were carried out on a field-cycling NMR spectrometer with B 0 = 7 T that is described before [24]. High field experiments and ultralow field SABRE [25] experiments were carried out on a Bruker AVANCE III HD NMR spectrometer with B 0 = 9.4 T. Enhancement factors were obtained in respect to corresponding thermal signal at 9.4 T for 15 N and at 7 T for 1 H. All spectra shown in the main text were recorded with a single scan.…”

“…For this reason, first of all we would like to see whether the stabilized complex can be used for generating hyperpolarization in conventional low-field SABRE experiments (LF-SABRE). For this purpose we used a field-cycling NMR spectrometer with B 0 = 7 T that allows one to bubble pH 2 through the solution at variable magnetic field from 0.1 mT up to 7 T and to detect high-resolution 1 H-NMR spectra [24] at the detection field B 0 within < 0.4 s. The principal experimental scheme of a LF-SABRE experiment is shown in Figure 1A. The LF-SABRE experiment consists of three stages: (stage 1) SABRE polarization is created at a field B by bubbling pH 2 through the solution, then (stage 2) during the time period τ fs ≈ 0.4 s sample is transferred to the detection field B 0 = 7 T, and, finally, (stage 3) after a 90° RF pulse the free induction decay (FID) is measured.…”

“…SABRE experiments at low magnetic fields are relatively simple, however, they require developing additional hardware for changing the external magnetic field and for shuttling the sample from the polarization to the detection field [24]. To get around these technical problems, recently several methods for generation of high-field SABRE polarization have been proposed [12,14,16,33].…”

Time‐Resolved Chemically Induced Dynamic Nuclear Polarization of Biologically Important Molecules

“…To couple light in and to direct it onto the sample one can use light‐guides or optical fibers. In the literature, schemes of sample irradiation from top as well as from the side have been described. In the latter case, irradiation is performed through a window of the NMR saddle‐shaped coil.…”

DOSY Analysis of Micromolar Analytes: Resolving Dilute Mixtures by SABRE Hyperpolarization

“…SABRE hyperpolarization. [18] In this work, we have employed the flow system described in Refs. During the lifetime of the complex, the spin order of pH 2 is converted to nuclear hyperpolarization in analytes.…”