Abstract-NLRP10 is one of the members of NODlike receptors (NLRs) family that is least characterized. It is a protein that takes part in pathogen sensing and responsible for the subsequent signaling propagation leading to immunologic response. In this study, computational tools such as algorithm, web server and database were used to investigate the domain of NLRP10 protein. The findings of this research may provide computational insights into the structure and functions of NLRP10, which in turn may foster better understanding of the role of NLRP10 in the immunologic defense.