A fast method for the detection of irinotecan in plasma samples by combining solid phase extraction and differential pulse voltammetry

Bonazza, Gregorio; Tartaggia, Stefano; Toffoli, Giuseppe; Polo, Federico; Daniele, Salvatore

doi:10.1007/s00216-020-02386-1

Cited by 8 publications

(6 citation statements)

References 45 publications

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“…In all cases, duplicate extraction recoveries did not differ by more than 6.5%. Literature studies have confirmed similar extraction recoveries from plasma, irrespective of irinotecan concentration: published recoveries were 66%-70% upon deproteinization with three volumes of 0.1% of acetic acid in methanol relative to plasma sample volume, or with one volume of acetonitrile relative to plasma sample volume 3,10,27 .…”

Section: Extraction Efficiencymentioning

confidence: 72%

“…Within this time range, irinotecan levels are typically above or at the LOQ of the here-in proposed assay in plasma matrix 2,24 . Additionally, quantifying irinotecan in plasma of treated patients within 0.5-3.0 h from drug infusion, when irinotecan levels are in the upper region of the therapeutic window is considered sufficient to decide on whether a subsequent dose adjustment is required 10 . Our assay in plasma may thus be useful for the purposes of personalised dose adjustment, or for calculating irinotecan AUC based on PK models.…”

Section: Useful Analytical Range Precision Lod and Loqmentioning

confidence: 99%

“…They were coupled with UV detection upon analysis of irinotecan dosage forms, or mainly with MS or fluorescence detection upon irinotecan analysis in biological fluids 3,[6][7][8][9] . A method based on solid phase extraction coupled with differential pulse voltammetry has recently been proposed for irinotecan quantification in plasma for personalised dose optimisation purposes 10 . Additionally, the fluorescence characteristics of irinotecan have been exploited for its direct determination in biological fluids and pharmaceuticals [11][12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

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A simple, rapid and low-cost spectrophotometric method for irinotecan quantification in human plasma and in pharmaceutical dosage forms

et al. 2021

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Section: Extraction Efficiencymentioning

confidence: 72%

Section: Useful Analytical Range Precision Lod and Loqmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A simple, rapid and low-cost spectrophotometric method for irinotecan quantification in human plasma and in pharmaceutical dosage forms

et al. 2021

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“…Teófilo et al used the DPV method to screen ecstasy compounds in the body using a boron-doped diamond electrode (BDD) [85]. In other research, DPV combined with solid phase extraction was used to measure irinotecan in a plasma matrix [86]. Huang, et al used a type of DPV with a triple application to increase sensitivity for the detection of DNA, as illustrated in Figure 10 [87].…”

Section: Differential Pulse Voltammetry (Dpv)mentioning

confidence: 99%

Determination of Drugs in Clinical Trials: Current Status and Outlook

Tavana

Chen

2022

Sensors

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All pharmaceutical drugs, vaccines, cosmetic products, and many medical breakthroughs must first be approved through clinical research and trials before advancing to standard practice or entering the marketplace. Clinical trials are sets of tests that are required to determine the safety and efficacy of pharmaceutical compounds, drugs, and treatments. There is one pre-phase and four main clinical phase requirements that every drug must pass to obtain final approval. Analytical techniques play a unique role in clinical trials for measuring the concentrations of pharmaceutical compounds in biological matrices and monitoring the conditions of patients (or volunteers) during various clinical phases. This review focuses on recent analytical methods that are employed to determine the concentrations of drugs and medications in biological matrices, including whole blood, plasma, urine, and breast milk. Four primary analytical techniques (extraction, spectroscopy, chromatography, and electrochemical) are discussed, and their advantages and limitations are assessed. Subsequent to a survey of evidence and results, it is clear that microelectromechanical system (MEMS) based electrochemical sensor and biosensor technologies exhibit several notable advantages over other analytical methods, and their future prospects are discussed.

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“…CYP3A4, cytochrome P-450; UGT1A1/7, UDPglucuronosyltransferase; CE, liver carboxylase adsorptive stripping square wave voltammetry and differential pulse voltammetry. These techniques were successfully applied to the detection of CPT-11 in biological samples [21][22][23]. A simple and efficient fluorimetric assay to detect the active metabolite SN-38 was also validated in plasma [24].…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a selective SPR aptasensor for the detection of anticancer drug irinotecan in human plasma samples

et al. 2021

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In this work, a surface plasmon resonance (SPR)-based assay for the quantification of antineoplastic drug irinotecan in human plasma samples has been developed for the first time. The selective binding of irinotecan with an aptamer receptor, operating in human plasma, allowed to set-up a novel analytical methodology to detect the drug in the analytical range of interest by using SPR as detection technique. After hybridizing the aptamer to the sensing platform and optimizing the sample preparation procedure, a quantitative assay was validated according to FDA regulatory guidelines. The analytical working range was found between 100 and 7500 ng mL −1 with negligible interferences from plasma components and co-medication associated with the administration of irinotecan. The utility of the new SPR assay was confirmed by analyzing plasma samples in parallel with LC-MS as reference technique, providing a new analytical tool for the therapeutic drug monitoring of irinotecan in patients under chemotherapy regimens.

show abstract

A fast method for the detection of irinotecan in plasma samples by combining solid phase extraction and differential pulse voltammetry

Cited by 8 publications

References 45 publications

A simple, rapid and low-cost spectrophotometric method for irinotecan quantification in human plasma and in pharmaceutical dosage forms

A simple, rapid and low-cost spectrophotometric method for irinotecan quantification in human plasma and in pharmaceutical dosage forms

Determination of Drugs in Clinical Trials: Current Status and Outlook

Development and validation of a selective SPR aptasensor for the detection of anticancer drug irinotecan in human plasma samples

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