A fast‐responsive fluorescent probe for sulfite and its bioimaging

Wang, Jiaoliang; Liu, Liping; Xiao, Xiaoming

doi:10.1002/bio.3023

Cited by 18 publications

(6 citation statements)

References 36 publications

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“…Adopting a similar strategy, Wang et al also developed a coumarin-cyanovinyl sulfite receptor 222 based on the nucleophilic addition mechanism to rapidly detect SO 3 2– in aqueous media combined with a fluorescence turn-on. 222 displays good water solubility, fast response times, and a high selectivity and sensitivity.…”

Section: Fluorescent Chemosensors Based On Coumarin Platforms For Rea...mentioning

confidence: 99%

Coumarin-Based Small-Molecule Fluorescent Chemosensors

et al. 2019

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Coumarins are a very large family of compounds containing the unique 2H-chromen-2-one motif, as it is known according to IUPAC nomenclature. Coumarin derivatives are widely found in nature, especially in plants and are constituents of several essential oils. Up to now, thousands of coumarin derivatives have been isolated from nature or produced by chemists. More recently, the coumarin platform has been widely adopted in the design of small-molecule fluorescent chemosensors because of its excellent biocompatibility, strong and stable fluorescence emission, and good structural flexibility. This scaffold has found wide applications in the development of fluorescent chemosensors in the fields of molecular recognition, molecular imaging, bioorganic chemistry, analytical chemistry, materials chemistry, as well as in the biology and medical science communities. This review focuses on the important progress of coumarin-based small-molecule fluorescent chemosensors during the period of 2012− 2018. This comprehensive and critical review may facilitate the development of more powerful fluorescent chemosensors for broad and exciting applications in the future.

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Section: Fluorescent Chemosensors Based On Coumarin Platforms For Rea...mentioning

confidence: 99%

Coumarin-Based Small-Molecule Fluorescent Chemosensors

et al. 2019

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“…Due to the slow response time, the maximum emission wavelength of the probe gradually changes, which is not suitable for real time detection of sulfite content in cells. So in 2015, Wang's [44] team made an improvement and designed probe 13, which incorporates an electron-withdrawing group (-CN) to accelerate the reaction with SO 2 derivatives by activating carbon-carbon double bonds, so that the reaction is completed within 1 min.…”

Section: Ict Mechanismsmentioning

confidence: 99%

Small-Molecule Fluorescent Probe for Detection of Sulfite

Chen

Wang

et al. 2022

Pharmaceuticals

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Sulfite is widely used as an antioxidant additive and preservative in food and beverages. Abnormal levels of sulfite in the body is related to a variety of diseases. There are strict rules for sulfite intake. Therefore, to monitor the sulfite level in physiological and pathological events, there is in urgent need to develop a rapid, accurate, sensitive, and non−invasive approach, which can also be of great significance for the improvement of the corresponding clinical diagnosis. With the development of fluorescent probes, many advantages of fluorescent probes for sulfite detection, such as real time imaging, simple operation, economy, fast response, non−invasive, and so on, have been gradually highlighted. In this review, we enumerated almost all the sulfite fluorescent probes over nearly a decade and summarized their respective characteristics, in order to provide a unified platform for their standardized evaluation. Meanwhile, we tried to systematically review the research progress of sulfite small−molecule fluorescent probes. Logically, we focused on the structures, reaction mechanisms, and applications of sulfite fluorescent probes. We hope that this review will be helpful for the investigators who are interested in sulfite−associated biological procedures.

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“…*Corresponding authors (email: kli@scu.edu.cn; xqyu@scu.edu.cn) To date, fluorescence sensing and imaging has been extensively developed as a powerful and versatile method in diverse fields because of its simplicity, excellent selectivity and high sensitivity compared to electrochemical techniques, UV-Vis spectroscopy, capillary electrophoresis, and chromatography [11][12][13][14]. A number of fluorescent probes for sulfite have been developed based on coumarin because of its good photo-stability properties and ease of preparation [15][16][17][18][19][20][21][22][23][24][25]. However, some problems with such probes can occur, such as having a small Stokes shift and a low quantum yield; also many studies have reported the need for an organic co-solvent to increase the solubility and reactivity of the probes, which might increase cell cytotoxicity and affect cell function [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

A novel coumarin-based water-soluble fluorescent probe for endogenously generated SO2 in living cells

Yang

Hou

et al. 2017

Sci. China Chem.

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A novel coumarin-based "turn-on" fluorescent probe SS-1 was developed for selective detection of SO2 derivatives in 100% water solution among reactive sulfur species (RSS). The detection limit of the method was 91.7 nM. Moreover, the probe exhibited low cytotoxicity and was successfully applied in the imaging of endogenously generated SO2 in HeLa cells. endogenously generated SO2, fluorescent probe, bioimaging Citation: XQ. A novel coumarin-based water-soluble fluorescent probe for endogenously generated SO2 in living cells. Sci China Chem,

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A fast‐responsive fluorescent probe for sulfite and its bioimaging

Cited by 18 publications

References 36 publications

Coumarin-Based Small-Molecule Fluorescent Chemosensors

Coumarin-Based Small-Molecule Fluorescent Chemosensors

Small-Molecule Fluorescent Probe for Detection of Sulfite

A novel coumarin-based water-soluble fluorescent probe for endogenously generated SO2 in living cells

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