A faster migrating Gc-variant: Gc Darmstadt

Group-Specific Component, Alphai-Antitrypsin and Esterase D in Canadian Eskimos

“…This is probably the same variant as Gc Esk reported in the Greenland Eskimos [22], Gc Esk was reported to be identical to Gc Ab by immunoelectrophoresis [16], with Gc D slower than Ab [5]. The anodal mobility of the Aboriginine and Darmstadt variants was found by polyacrylamide gel electrophoresis and crossed im munoelectrophoresis to be Gc A b> G c D > G c I [5].…”

“…This is probably the same variant as Gc Esk reported in the Greenland Eskimos [22], Gc Esk was reported to be identical to Gc Ab by immunoelectrophoresis [16], with Gc D slower than Ab [5]. The anodal mobility of the Aboriginine and Darmstadt variants was found by polyacrylamide gel electrophoresis and crossed im munoelectrophoresis to be Gc A b> G c D > G c I [5]. The relative mobilities by immunofixation after agarose electrophoresis at pH 8.6 have been pre viously reported as Gc D = Gc E sk(= present variant Gc lgl)>G c Ab [15], Our studies indicate that the relative mobilities are Gc D Gc Ab Gc Esk = Gc Igl.…”

“…The fast variant was compared with the Eskimo variant reported in Greenland Eskimos (Gc Esk) [22], with Gc Aboriginine (Gc Ab) and Gc Darmstadt (Gc D) [5]. The variant in our Eskimo population was probably identical to that described in Greenland Eskimos, although the latter sample was degraded and did not produce sharp bands.…”

Gc Opava: a Variant of the Group-Specific Component (Gc) System with an Electrophoretic Mobility Intermediate between Gc 1-1 and Gc 2-2

“…Aliquots were sent to New York by airmail and stored frozen at -20°C prior to analysis. Immunoelectrophoresis and antigen-antibody crossed gel electrophoresis were carried out as described previously [3]. Figure 1 shows the immunoelectrophoretic analysis of the two variant phenotypes in comparison with common Gc types.…”

“…Some of these variants occur in certain populations at polymorphic frequencies as, for example, Gc Aborigine and Gc Chippewa [2]. Other variants are quite infrequent and have been observed only in a few or in single families as, for instance, Gc Norway [11], Gc Z [4], Gc Bangkok [12], Gc Darmstadt [3], Gc Japan [8] and Gc Wien [13]. The information avail able on these Gc mutants has been discussed more fully in a recent review [1].…”