A Fatal Case of Acute Myocardial Infarction following the Improvement of Influenza A(H1N1)pdm2009-related Acute Myocarditis

Iwanaga, Naoki; Nakamura, Shigeki; Fukuda, Yuichi; Takazono, Takahiro; Imamura, Yoshifumi; Izumikawa, Koichi; Yanagihara, Katsunori; Soda, Hiroshi; Tashiro, Takayoshi; Kohno, Shigeru

doi:10.2169/internalmedicine.53.2435

Cited by 7 publications

(5 citation statements)

References 22 publications

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“…There have been approximately 44 cases of influenza‐associated myocarditis in adult patients described in case reports and case series (Table ) . Among those reported, 52% (23/44) occurred in men and 68% (30/44) occurred in patients under 40 years of age.…”

Section: Resultsmentioning

confidence: 99%

The hidden burden of influenza: A review of the extra‐pulmonary complications of influenza infection

Sellers

Hagan

Hayden

et al. 2017

Influenza Resp Viruses

336

308

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Severe influenza infection represents a leading cause of global morbidity and mortality. Although influenza is primarily considered a viral infection that results in pathology limited to the respiratory system, clinical reports suggest that influenza infection is frequently associated with a number of clinical syndromes that involve organ systems outside the respiratory tract. A comprehensive MEDLINE literature review of articles pertaining to extra‐pulmonary complications of influenza infection, using organ‐specific search terms, yielded 218 articles including case reports, epidemiologic investigations, and autopsy studies that were reviewed to determine the clinical involvement of other organs. The most frequently described clinical entities were viral myocarditis and viral encephalitis. Recognition of these extra‐pulmonary complications is critical to determining the true burden of influenza infection and initiating organ‐specific supportive care.

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Section: Resultsmentioning

confidence: 99%

The hidden burden of influenza: A review of the extra‐pulmonary complications of influenza infection

Sellers

Hagan

Hayden

et al. 2017

Influenza Resp Viruses

336

308

View full text Add to dashboard Cite

show abstract

“…In literature we found some case reports on rhythm disorders in swine flu like VF, AF, complete heart block, first degree heart block, bradycardia and wide complex tachycardia [13,14,16,20]. Although precise mechanisms by which ECG manifestations are produced in H1N1 influenza are still unknown it may be a direct cytolytic effect of virus on myocardial cells with cytotoxic immunologic interaction, ischemia due to intracapillary thrombosis, inflammatory edema pressing AV node and other conduction tissue or primarily affecting conduction tissue/AV nodal pacemaker cells resulting in resting membrane potential changes [13,21,22].…”

Section: Discussionmentioning

confidence: 99%

“…In our study 4 patients developed STEMI, 2 of them were known case of pre-existing CAD and 2 were not (one 60 year old male and the other 64 year female), the values of Troponin I, NT-proBNP and CPK-MB in these 2 new cases was highly raised (778.2/7164/8.94 and 190.9/7016/6.3 respectively). It has been shown that influenza may precipitate MI [20,22,23]. It has also been observed that incidence…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Cardiovascular System Involvement in Hospitalized Cases of Swine Flu

Bk¹,

Rk²,

Gupta³

et al. 2020

J Emerg Dis Virol

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Swine flu H1N1 is a novel strain of Influenza A virus that is evolved by genetic reassortment and its infection in human being can lead to varying degree of respiratory infections ranging from mild flu to severe and life-threatening pneumonia, bronchitis, acute respiratory distress syndrome with high mortality [1].Epidemiologic studies have noted an increase in cardiovascular deaths during influenza epidemics indicating that cardiovascular complications of influenza infection, including exacerbation of heart failure, acute ischemic heart disease, and less often acute myocarditis, are important contributors to morbidity and mortality during influenza infection. This effect was observed in both genders at all age groups [2].A study in the United States has previously estimated that influenza causes up to 92000 deaths per year by triggering Acute Myocardial

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“…There were also 11 exacerbations COPD of and one case with severe myocarditis. Several studies have described myocarditis as a severe complicating form of influenza [ 17 , 18 ] and COPD is an independent risk factor for poor clinical outcomes in influenza and hospitalization in intensive care [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Characteristics and outcome of ill critical patients with influenza A infection

Bouneb¹,

Mellouli²,

Bensoltane³

et al. 2018

Pan Afr Med J

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IntroductionTo describe all patients admitted to Tunisian intensive care unit with a diagnosis of influenza A/H1N1 virus infection after the 2009 influenza pandemic and to analyse their characteristics, predictors of complications and outcome.MethodsAll patients with influenza > 18-years-old hospitalized to the ICU department of Tunisian University hospital of Sousse, between December 1, 2009 and March 31, 2016, with a positive influenza A/H1N1/09 reverse transcriptase polymerase chain reaction (RT-PCR) from a nasopharyngeal specimen were included, were included.Results40 cases were admitted to intensive care units. During the reporting period, 22 deaths in intensive care units (55%) were reported, the median age was 53 years (IQR 37-61), 24 (61%) were male, The median scores SAPS II and SOFA were respectively 29 (IQR 23-36) and 6 (IQR 3-10), 27% had chronic obstructive pulmonary disease (COPD), 33.3% diabetic and no patients were vaccinated against influenza A. The cause of admission was in 72.5% of the cases was hypoxemic pneumonae. By using a logistic regression, we found after adjustment to age, that acute respiratory distress syndrome (ARDS) (OR = 27; 95%CI: 3.62-203.78) was the only factor significantly associated with severe outcomes of the cases.ConclusionPatients in the first post pandemic season were significantly older and more frequently had underlying medical conditions. Multivariate analysis showed that older male patients with chronic lung disease were at increased risk for a severe clinical outcome.

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A Fatal Case of Acute Myocardial Infarction following the Improvement of Influenza A(H1N1)pdm2009-related Acute Myocarditis

Cited by 7 publications

References 22 publications

The hidden burden of influenza: A review of the extra‐pulmonary complications of influenza infection

The hidden burden of influenza: A review of the extra‐pulmonary complications of influenza infection

Evaluation of Cardiovascular System Involvement in Hospitalized Cases of Swine Flu

Characteristics and outcome of ill critical patients with influenza A infection

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