A fatal case of early prosthetic valve endocarditis caused by multidrug-resistant (MDR) – Sphingomonas paucimobilis

Saboe, Aninka; Adrian, Yudri; Widyatmoko, Leonardus; Hasan, Melawati; Cool, Charlotte Johanna; Hartantri, Yovita; Rahmadi, Andri Reza; Nusjirwan, Rama; Akbar, Mohammad Rizki

doi:10.1016/j.idcr.2021.e01152

Cited by 8 publications

(6 citation statements)

References 17 publications

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“…A case series by Lin et al has shown that the most effective antimicrobials were fluoroquinolones, β-lactam/β-lactamase inhibitor combinations, carbapenems, and aminoglycosides [10] . One recently published case report of early prosthetic valve endocarditis presented a multidrug-resistant S. paucimobilis that was only susceptible to tigecycline [16] . Our patient was treated with a 6-week meropenem regimen in the lack of an antibiogram to this germ.…”

Section: Discussionmentioning

confidence: 99%

“…Comparably, another retrospective study addressing the epidemiology and the prognosis of healthcare-associated endocarditis in China included a single case of infective endocarditis caused by S. paucimobilis [20] . And finally, Saboe et al has recently published a fatal case of MDR S. paucimobilis causing an early prosthetic valve endocarditis with multivalvular involvement and perivalvular abscess, that was only sensitive to tigecycline [16] .…”

Section: Discussionmentioning

confidence: 99%

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Sphingomonas paucimobilis native valve endocarditis and mycotic cerebral aneurysm in a patient with Crohn’s disease: Case report and review of literature

Assi

Hammoud

Ezzedine

et al. 2023

IDCases

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sphingomonas paucimobilis native valve endocarditis and mycotic cerebral aneurysm in a patient with Crohn’s disease: Case report and review of literature

Assi

Hammoud

Ezzedine

et al. 2023

IDCases

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“…Reports described S. paucimobilis in clinical specimens, blood, urine, endotracheal aspirates, bronchoalveolar lavage, and cerebrospinal fluid of patients with septicemia, meningitis, lower respiratory tract infections, and ventilator-associated pneumonia (Rohilla et al, 2021). Cases of early prosthetic valve infective endocarditis caused by MDR S. paucimobilis have been reported (Saboe et al, 2021). The S. paucimobilis (ILH14) isolated here was identified using the MALDI-TOF MS technique with phenotyping of MDR antibiotics the quinolone, penicillin, aminoglycoside, polymyxin, tetracycline, and oxazolidinone classes.…”

Section: Discussionmentioning

confidence: 99%

Resistance determinants of emerging pathogens isolated from an intensive care unit as a parameter of population health conditions of the Legal Amazon microregion

et al. 2023

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Bacteria responsible for causing infections are common in hospital environments, water, soil, and food products. The infection risk is intensified by the absence of public sanitation, poor quality of life, and food scarcity. These external factors promote the dissemination of pathogens by direct contamination or biofilm formation. In this work, we identified bacterial isolates obtained from intensive care units in the southern region of Tocantins, Brazil. We compared matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) techniques and 16S ribosomal ribonucleic acid (rRNA) molecular analysis; we also performed phenotypic characterization. Fifty-six isolates characterized using morphotinctorial tests were classified as gram-positive (80.4%; n = 45) and gram-negative (19.6%; n = 11) and were resistant to several antibiotic classes; notably, we identified the blaOXA-23 resistance gene in the ILH10 isolate. Microbial identification using MALDI-TOF MS resulted in the identification of Sphingomonas paucimobilis and Bacillus circulans. 16S rRNA sequencing revealed four isolates belonging to the genera Bacillus and Acinetobacter. The similarity was superior to 99% for Acinetobacter schindleri in the Basic Local Alignment Search Tool (BLAST), grouped in the clade superior to 90%. Several strains isolated from intensive care units (ICU) were resistant to various antibiotic classes. These techniques allowed for the identification of several microorganisms of importance in public health, enabling improvements in human infection control and proving the quality of inputs, food, and water.

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“…The sphingans group has applications in a variety of industries as food, cement, personal care, abiotic stress tolerance, bioremediation, and biodegradation, etc. Malleobactin is a member of the siderophore family and has an important role in plant resistance to pathogens (Xiao et al, 2020;Saboe et al, 2021). Zeaxanthin has significant commercial value for its antioxidant potential and is widely used in the food, cosmetic and pharmaceutical industries.…”

Section: Metabolite Biosynthesis Gene Clusters Analysismentioning

confidence: 99%

A nostoxanthin-producing bacterium, Sphingomonas nostoxanthinifaciens sp. nov., alleviates the salt stress of Arabidopsis seedlings by scavenging of reactive oxygen species

et al. 2023

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A novel, nostoxanthin-producing, endophytic bacterium, designated as AK-PDB1-5T, was isolated from the needle-like leaves of the Korean fir (Abies koreana Wilson) collected from Mt. Halla in Jeju, South Korea. A 16S rRNA sequence comparison indicated that the closest phylogenetic neighbors were Sphingomonas crusticola MIMD3T (95.6%) and Sphingomonas jatrophae S5-249T (95.3%) of the family Sphingomonadaceae. Strain AK-PDB1-5T had a genome size of 4,298,284 bp with a 67.8% G + C content, and digital DNA–DNA hybridization and OrthoANI values with the most closely related species of only 19.5–21% and 75.1–76.8%, respectively. Cells of the strain AK-PDB1-5T were Gram-negative, short rods, oxidase- and catalase-positive. Growth occurred at pH 5.0–9.0 (optimum pH 8.0) in the absence of NaCl at 4–37°C (optimum 25–30°C). Strain AK-PDB1-5T contained C14:0 2OH, C16:0 and summed feature 8 as the major cellular fatty acids (> 10%), while sphingoglycolipid, phosphatidylethanolamine, phosphatidylglycerol, phospholipids and lipids were found to be the major polar lipids. The strain produces a yellow carotenoid pigment; natural products prediction via AntiSMASH tool found zeaxanthin biosynthesis clusters in the entire genome. Biophysical characterization by ultraviolet–visible absorption spectroscopy and ESI-MS studies confirmed the yellow pigment was nostoxanthin. In addition, strain AK-PDB1-5T was found significantly promote Arabidopsis seedling growth under salt conditions by reducing reactive oxygen species (ROS). Based on the polyphasic taxonomic analysis results, strain AK-PDB1-5T was determined to be a novel species in the genus Sphingomonas with the proposed name Sphingomonas nostoxanthinifaciens sp. nov. The type strain is AK-PDB1-5T (= KCTC 82822T = CCTCC AB 2021150T).

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A fatal case of early prosthetic valve endocarditis caused by multidrug-resistant (MDR) – Sphingomonas paucimobilis

Cited by 8 publications

References 17 publications

Sphingomonas paucimobilis native valve endocarditis and mycotic cerebral aneurysm in a patient with Crohn’s disease: Case report and review of literature

Sphingomonas paucimobilis native valve endocarditis and mycotic cerebral aneurysm in a patient with Crohn’s disease: Case report and review of literature

Resistance determinants of emerging pathogens isolated from an intensive care unit as a parameter of population health conditions of the Legal Amazon microregion

A nostoxanthin-producing bacterium, Sphingomonas nostoxanthinifaciens sp. nov., alleviates the salt stress of Arabidopsis seedlings by scavenging of reactive oxygen species

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