A fatal case of gastrointestinal mucormycosis in immunosuppressed host

Kalva, Nikhil; Somaraju, Vijaya; Puli, Srinivas R.

doi:10.1016/j.mjafi.2013.05.006

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…Clinical features of GI mucormycosis are nonspecific, which includes abdominal pain and distention, nausea and vomiting, hematemesis, hematochezia, and intestinal perforation with peritonitis where our case presented with hematochezia [10] . It may present with bowel obstruction.…”

Section: Clinical Discussionmentioning

confidence: 74%

Mucormycosis-unusual cause of lower GI bleeding: A rare case report

Shrestha

Maharajan

Pradhan

et al. 2021

International Journal of Surgery Case Reports

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Introduction Mucormycosis is a rare systemic fungal infection seen in immune-compromised patients. Gastrointestinal tract involvement is not usual. Case presentation A 36 years female presented with fever and progressive bilateral leg swelling for 25 days. She was diagnosed as nephrotic syndrome and started on methylprednisolone and cyclophosphamide. She developed hematochezia during hospital stay. On colonoscopy, ulcero-proliferative lesion was noted in caecum. Histopathology examination has confirmed it as mucormycosis of Caecum. Discussion Mucormycosis is an opportunistic angioinvasive disease caused by fungus zygomycosis it is a rare disease and often manifests as a life-threatening condition in immune-compromised patient. Invasion by fungal hyphae leads to arterial thrombosis, tissue infarction, hemorrhage and, necrosis. Diagnosis is confirmed by histopathological examination and culture. It is usually treated by the anti-fungal drug- liposomal amphotericin and surgical debridement. Conclusion Mucormycosis is a fatal systemic fungal infection, which can present as lower gastrointestinal bleeding in immunocompromised patients.

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Section: Clinical Discussionmentioning

confidence: 74%

Mucormycosis-unusual cause of lower GI bleeding: A rare case report

Shrestha

Maharajan

Pradhan

et al. 2021

International Journal of Surgery Case Reports

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“…Patients should be diagnosed based on their histological findings, since the culture is positive in only 30% of surgical specimens [ 5 ]. Treatment is a combination of early surgical debridement of infected tissue, along with systemic antifungal therapy (usually parenteral amphotericin B at 1 mg/kg/day or oral posaconazole at 400 mg, given twice daily) [ 1 , 6 , 7 ]. Early intervention with a combined approach will give the patient a better chance of survival, up to 70% [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

An unusual cause of acute anemia in an immunosuppressed patient

Esfeh

Jackson

Ansari-Gilani

et al. 2015

Gastroenterol. Rep.

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Gastrointestinal mucormycosis is an uncommon, invasive, opportunistic fungal infection with a high mortality rate, seen more commonly in immunocompromised patients. This lethal infection has a wide range of presentations, from colonization of peptic ulcers to infiltrative disease and eventually vascular invasion. Here we present a case of upper gastrointestinal bleeding in an immunocompromised patient, which was proved to be secondary to gastric involvement by mucormycosis.

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“…Patients should be diagnosed based on their histological findings, since the culture is positive in only 30% of surgical specimens [5]. Treatment is a combination of early surgical debridement of infected tissue, along with systemic antifungal therapy (usually parenteral amphotericin B at 1 mg/kg/day or oral posaconazole at 400 mg, given twice daily) [1,6,7]. Early intervention with a combined approach will give the patient a better chance of survival, up to 70% [3].…”

Section: Discussionmentioning

confidence: 99%