A Fatal Case of Large Cell Neuroendocrine Lung Cancer Metastatic to the Brain: A Case Report

Abstract

Garcia de de Jesus et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Brain Metastasis: Clinical and Biological Approach

“…Garcia de de Jesus et al described another case: A 63-year-old female with frontal headaches with an abnormal motor exam. MR and Computed Tomography (CT) revealed tumor masses in the thorax and brain [11]. The anatomopathological analysis of the craniotomy was compatible with large cell neuroendocrine lung cancer that had led to brain metastasis.…”

“…The anatomopathological analysis of the craniotomy was compatible with large cell neuroendocrine lung cancer that had led to brain metastasis. These cases demonstrate the importance of creating targeted clinical trials for aggressive cancers to provide more specific treatment and the key role of the diagnosis [11]. Another cancer with a large number of metastases developing in the brain is breast cancer.…”

Management of an Unusual Central Nervous System Metastasis With Linear Accelerator Radiosurgery in a Low-Middle Income Country

“…The treatment for localized disease follows partly the guidelines of treatment for SCLC and NSCLC consisting in surgical removal of the localized tumor plus neoadjuvant or adjuvant chemotherapy composed of a combined scheme of cisplatin and etoposide from four to six cycles [6,[13][14][15][16]. Our patient's clinical history is coherent with the reported age of presentation although his clinical debut deviates from what is reported in the literature since he did not present most of the symptoms commonly associated with an LCNEC of the lung (cough, hemoptysis, dyspnea, and night sweats); although, he did present an asymptomatic nodule and chest pain [13]. As mentioned earlier, through the biopsy the definite diagnosis of a high-grade stage 3 NSCLC was made, and the treatment mentioned beforehand was initiated.…”

Metastatic large cell neuroendocrine lung cancer to the foramen magnum

“…The other is that the site of metastasis to the foramen magnum is extremely rare. We searched PubMed using the term “neuroendocrine lung cancer”, and 12 English reports of clinical cases were reviewed [ 1 – 12 ] (Table 1 ). Among these cases, there were 7 female patients and 5 male patients.…”

“…Neuroendocrine tumors are epithelial neoplasms with predominant neuroendocrine differentiation and, while typically seen of pulmonary origin, can arise in most organs. [ 1 ] The 2004 World Health Organization (WHO) classification proposed four subtypes of pulmonary neuroendocrine (NE) tumors: low-grade typical carcinoid (TC), intermediate-grade atypical carcinoid (AC) and two high-grade tumors, large cell neuroendocrine carcinoma (LCNEC) and small-cell lung carcinoma (SCLC). LCNECs of the lung represent a rare subtype of primary lung cancer accounting for only 2.9% of cases.…”