A fatal case of pulmonary nocardiosis

Patil, Mahantesh; Shivaprasad, C; Varghese, Jaicob; Rajagopalan, Natarajan

doi:10.1136/bcr.09.2011.4875

Cited by 8 publications

(16 citation statements)

References 10 publications

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“…[20,26] So, early diagnosis and prompt initiation of treatment are of vital importance in Nocardia infection. [28] In this case, overdelayed diagnosis and intervention definitely attributes to the eventual death.…”

Section: Discussionmentioning

confidence: 97%

Severe pneumonia due to Nocardia otitidiscaviarum identified by mass spectroscopy in a cotton farmer

Liu¹,

Feng²,

Zhu³

et al. 2017

Medicine

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Rationale:Nocardia species are aerobic saprophytic bacilli. Among Nocardia species, Nocardia otitidiscaviarum (N otitidiscaviarum) is rarely reported in pulmonary infection.Patient concerns:We reported a case of N otitidiscaviarum pneumonia in a cotton farmer.Diagnoses:N otitidiscaviarum pneumonia was identified by mass spectroscopy.Interventions:Combined treatments (amikacin, imipenem and trimethoprim-sulfamethoxazole) were administered after identification of N otitidiscaviarum.Outcomes:The patient eventually died from severe respiratory insufficiency in the hospital.Lessons:Early precise diagnosis and prompt combined therapy are of vital importance in severe Nocardia pulmonary infection.

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Section: Discussionmentioning

confidence: 97%

Severe pneumonia due to Nocardia otitidiscaviarum identified by mass spectroscopy in a cotton farmer

Liu¹,

Feng²,

Zhu³

et al. 2017

Medicine

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“…In developing countries, including the United States of America, it has been noted that more than 60% of human nocardiosis occurs in immunocompromised individuals and that males are more prone to infection than females (3:1) [ 8 , 16 - 21 ]. The data on human nocardiosis is limited in the literature and is usually present as isolated case reports undermining its significance in human infection [ 22 - 24 ]. Persistent and disseminated human infection with Nocardia cyriacigeorgica in an otherwise immunocompetent individual was reported recently in the literature which was treated employing a strategic combination therapy that lasted for more than a year.…”

Section: Reviewmentioning

confidence: 99%

Human Nocardia Infections: A Review of Pulmonary Nocardiosis

Kandi¹

2015

Cureus

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Human nocardiosis may present as an acute or a chronic infection. Although a saprophyte Nocardia spp are responsible for superficial skin infections, pulmonary infections, and disseminated nocardiosis usually involving patients who are immunosuppressed and debilitated. Infections in immunocompetent individuals are usually chronic and present non-specific symptoms. Invasive and disseminated nocardiosis is common among patients with weakened cellular immune systems. Clinical diagnosis of pulmonary nocardiosis is difficult owing to the similarity of its presentation with other respiratory pathogens that include Actinomycetes members and Mycobacterium tuberculosis. Laboratory diagnosis of human nocardiosis is plagued by the fact that a culture of Nocardia spp requires prolonged incubation periods for isolation which most laboratories fail to follow. The lack of clinical, laboratory, and epidemiological data on the incidence of nocardiosis in humans undermines its significance as a potential pathogen. This review attempts to reexamine the pathogenic potential of Nocardia in human infections

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“…There are few documented cases of pulmonary nocardiosis affecting adult immunocompetent patients,7–9 and they are mostly associated with pulmonary chronic disease (such as bronchiectasis, chronic obstructive pulmonary disease or asthma) 10–13. There are also reports of previously healthy children having nocardiosis associated with pneumonia and pleural effusion, central nervous system infection and septic arthritis 14–17…”

Section: Discussionmentioning

confidence: 99%

Nocardialung abscess in an immunocompetent adolescent

Soares¹,

Reis-Melo

Ferraz

et al. 2019

BMJ Case Rep

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The authors report a case of a lung abscess caused by Nocardia sp. in a previously healthy adolescent. A 17-year-old young man presented with tonsillitis that did not respond to β-lactamic antibiotic, dyspnoea and thoracic pain. The X-ray revealed a cavitation in the right pulmonary upper lobe. He was admitted and completed a 14-day empirical antimicrobial therapy for a pulmonar abscess, although no clinical recovery was observed. He then underwent pulmonary biopsy of the lesion and PCR analysis of the collected pulmonary tissue, which revealed the presence of Nocardia. This case emphasises the importance of considering nocardiosis in the differential diagnosis of a lung abscess, particularly if no response to empirical therapy is obtained.

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A fatal case of pulmonary nocardiosis

Cited by 8 publications

References 10 publications

Severe pneumonia due to Nocardia otitidiscaviarum identified by mass spectroscopy in a cotton farmer

Severe pneumonia due to Nocardia otitidiscaviarum identified by mass spectroscopy in a cotton farmer

Human Nocardia Infections: A Review of Pulmonary Nocardiosis

Nocardialung abscess in an immunocompetent adolescent

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