A fatal case of transfusion‐transmitted <i>Staphylococcus epidermidis</i> sepsis

Goldman, Mindy; Delage, Gilles; Beauregard, Patrice; Pruneau‐Fortier, Denise; Ismaïl, Johanne; Robillard, Pierre

doi:10.1046/j.1537-2995.2001.41081075.x

Cited by 33 publications

(35 citation statements)

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“…Similarly, 51 patients who received bacterially contaminated platelets and were receiving antibiotic therapy at the time of transfusion did not manifest any type of symptoms. We isolated mostly gram-positive bacteria, primarily coagulase-negative staphylococci, from contaminated platelets, which is concordant with published literature 9,11,28 and indicates contamination from the donors' skin flora. Coagulase-negative staphylococci have been involved in severe sepsis after transfusion of contaminated platelets, 12 but most cases of severe sepsis are secondary to contamination with gram-negative organisms, in which endotoxin can contribute to morbidity.…”

Section: Discussionsupporting

confidence: 90%

“…2 The outcome for patients infused with bacterially contaminated blood components ranges from no clinical effects to life-threatening consequences, 3 with transfusion-associated sepsis being the most severe result. 1,[4][5][6][7][8][9][10] The reported risk of death from transfusion of a bacterially contaminated unit of platelets varies considerably in the literature, 2,11,12 with a recent estimate of 1 death in 781,936 platelet transfusions and a contamination rate of 16.6 per 100,000 donations. 13 Low clinical impact is probably the result of multiple factors, including the amount of bacteria in the platelet unit, the species and virulence of the contaminating organism, the underlying disease of the patient, the concurrent status of antibiotic therapy, and the length of time the unit is stored.…”

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confidence: 99%

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Impact on Patient Outcome Following Transfusion of Bacterially Contaminated Platelets

Martínez

Tarrand

Lichtiger

2010

American Journal of Clinical Pathology

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This study examined the clinical outcome of every patient who received a bacterially contaminated unit of platelets at The University of Texas M.D. Anderson Cancer Center, Houston, during 2007. Samples of platelets were aerobically cultured and read for 1 day at 35 degrees C. Positive bottles were subcultured in the appropriate media. The effect of independent variables in the clinical outcome of patients infused with bacterially contaminated platelet units was analyzed. A total of 23,199 platelet units were transfused, 71 of which were bacterially contaminated units; 8 were apheresis platelets and 63 were whole blood platelets. Of the 71 units, 70 were contaminated with gram-positive bacteria and 1 with gram-negative bacteria. Only 1 patient developed fever, and coagulase-negative staphylococci were isolated from the transfused unit. Transfusion of fresh units and antibiotic therapy possibly explain the lack of clinical consequences in our patients.

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Section: Discussionsupporting

confidence: 90%

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confidence: 99%

Impact on Patient Outcome Following Transfusion of Bacterially Contaminated Platelets

Martínez

Tarrand

Lichtiger

2010

American Journal of Clinical Pathology

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“…Therefore, S. epidermidis strains especially emerge as life-threatening pathogens triggering septicaemia, meningitis and other serious conditions in medical device using and immunocomprised patients (Goldman et al , 2001; Guiot et al , 1994; Poutsiaka et al , 2007; Ziebuhr et al , 2006). One of the most important mechanisms making these commensal inhabitants dangerous for medical device using and immunocomprised patients is known as biofilm formation.…”

Section: Introductionmentioning

confidence: 99%

Multi drug resistance in strong biofilm forming clinical isolates of Staphylococcus epidermidis

Şahal¹,

Bilkay²

2014

Braz. J. Microbiol.

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Staphylococcus epidermidis which exists in healthy human skin as a commensal inhabitant is also an important pathogen forming biofilms on many surfaces and recently, increased resistance traits were suggested to be acquired in biofilm environments. In this study; clinical Prevalences, antibiotic resistances and biofilm formations of S. epidermidis strains were determined and comparison of all these findings with each other was carried out in order to take precautions against them and figure out if high biofilm forming S. epidermidis strains display multi drug resistance. According to our results; samples of wound and blood were the most S. epidermidis isolated clinical materials (40%; 35%) and cardiothoracic surgery was the most S. epidermidis observed service unit. All of these strains were sensitive to vancomycin, however 65% of them showed resistance to all β-lactam antibiotics (Penicillin, Oxacillin, Amoxicilin/Clavulonic acid), used in this study and 60% of all S. epidermidis strains were found as multi drug resistant. When the results of strong biofilm forming S. epidermidis strains are examined; they were isolated from sample of blood and service unit of cardiovascular surgery in highest frequency and 80% of them were β-lactam resistant whereas 100% of them were multi drug resistant. One of these multi drug resistant strains which was resistant to maximum amount of different antimicrobial classes, was also observed as maximum biofilm forming strain among all the other S. epidermidis isolates. Multi drug resistance in strong biofilm forming strains shows that; biofilms play a role in antimicrobial resistance traits of S. epidermidis.

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“…other serious conditions (Guiot et al, 1994;Goldman et al, 2001;Poutsiaka et al, 2007). All S. epidermidis infections are considered as being extremely recalcitrant to therapy.…”

Section: Introductionmentioning

confidence: 99%

Success through diversity – How Staphylococcus epidermidis establishes as a nosocomial pathogen

Schoenfelder

Lange

Eckart

et al. 2010

International Journal of Medical Microbiology

126

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A fatal case of transfusion‐transmitted Staphylococcus epidermidis sepsis

Cited by 33 publications

References 5 publications

Impact on Patient Outcome Following Transfusion of Bacterially Contaminated Platelets

Impact on Patient Outcome Following Transfusion of Bacterially Contaminated Platelets

Multi drug resistance in strong biofilm forming clinical isolates of Staphylococcus epidermidis

Success through diversity – How Staphylococcus epidermidis establishes as a nosocomial pathogen

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