A fatal outcome from rhinocerebral mucormycosis after dental extractions: A case report

Rhino Cerebral Mucormycosis with Post Surgical Complications in Diabetes: A Case Report

“…kidney and liver. 11,12,15 The term rhinocerebral mucormycosis (RCM) should be used when the paranasal sinuses, orbit and brain are Photomicrograph from retro-molar region showing elongated, broad, non-septate branching hyphae within the tissue and the bone marrow space (Gomori methenamine silver nitrate stain, original magnification _400) infections. A few studies have shown that HBO has direct in vitro fungistatic activity and reduce tissue hypoxia, which may reverse the hypoxic acidosis that helps the fungi to proliferate 25 .…”

“…The use of amphotericin B in patients with mucormycosis has been widely published and accepted as the best form of treatment with an overall survival rate of up to 72%. 15,16,18 Based on recent published data, Spellberg et al highlighted the recommended use of liposomal amphotericin B such as Am Bisome in the management of mucormycosis. 22 Surgical management is crucially important and should involve early debridement of all infected and necrotic tissues.…”

“…16 Patients with rhinocerebral mucormycosis usually present with malaise, headache, facial pain, swelling and low grade fever. 15 Rhino cerebral mucormycosis usually begins in the nasal mucosa or palate and extends to the paranasal sinuses, spreading via the angular, lacrimal, and ethmoid vessels as well as by direct extension from the sinuses into the retro-orbital region. Once fungal hyphae enter into the blood stream they can disseminate to other organs such as cerebrum or lungs which can be fatal for the patient.…”

“…In our case the patient developed meningitis 3 times and was successfully treated with broad spectrum antibiotics. Kim et al (2001) reported 4 cases of RM over a period of ten years, which were diagnosed postdental extractions. In all these 4 cases, the patients had an uncontrolled DM with two of them in a DKA state at the time of presentation 15 .…”

“…Kim et al (2001) reported 4 cases of RM over a period of ten years, which were diagnosed postdental extractions. In all these 4 cases, the patients had an uncontrolled DM with two of them in a DKA state at the time of presentation 15 . Even though mucormycosis of the head and neck commonly…”